Amide bonds in pharmaceuticals and other applications are generally formed through amination of carboxylic acid derivatives. However, access toN- trifluoromethyl amides via a procedure analogous to this most common strategy for amide-bond formation has yet to be described. Here, the synthesis ofN-...
Pasha, M.A.; Jayashankara, V.P. Synthesis of amides from carboxylic acids and urea in the presence of pyridine under microwave irradiation. J. Ind. Chem. Soc. 2005, 82, 675-676.Synthesis of amides from carboxylic acids and urea in the presence of pyridine under microwave irradiation. ...
ChemInform Abstract: A Convenient Synthesis of Amides, e.g. (III), from Carboxylic Acids, e.g. (I), and Primary Amines (IIa), (IIb)carboxylic amides (benzene compoundsNo abstract is available for this article.doi:10.1002/chin.199001136...
Solvent-free preparation of amides from acids and primary amines under microwave irradiation Synthesis of amides via pyrolysis of the salts obtained by mixing neat primary amines and carboxylic acids were realized under solvent-free conditions with... Laurence Perreux a,André Loupy a,Franois Volatron...
A plausible mechanism, which features distinctive Pd-II-mediated decarbonylative coupling and unprecedented nucleophilic attack of carboxylates to Pd-II-ligated isocyanides, was proposed to account for this reaction.关键词: Amides Carboxylic acids Palladium Decarbonylation Isocyanides ...
Therefore, the direct amidation of esters with amines, without the conversion into carboxylic acids, is a highly desirable approach for the formation of amides1 as esters are common synthetic intermediates of the target compounds. Fig. 1: Various synthetic methods for amide bonds. a Several ...
α-Tertiary amides are of great importance for medicinal chemistry. However, they are often challenging to access through conventional methods due to reactivity and chemoselectivity issues. Here, we report a single-step approach towards such amides via c
The functional group tolerance was also very interesting since carboxylic acids, amides as well as nitriles are tolerated under the reaction conditions. The synthesis of N-trifluoromethyl carbamoyl fluorides has also been undertaken by the group of Schoenebeck [23], [24]. The authors demonstrated ...
Tunoori AR, White JM, Georg GI (2000) A one-flask synthesis of Weinreb amides from chiral and achiral carboxylic acids using the Deoxo-Fluor fluorinating reagent. Org Lett 2(25):4091-4093Tunoori AR, White JM, Georg GI (2000) A one-flask synthesis of Weinreb amides from chiral and ...
ChemInform Abstract: Synthesis of Amides Under the Shock Wave Compression of Ammonium Salts of Saturated Carboxylic Acidscarboxylic amides (acyclic compoundsNo abstract is available for this article.doi:10.1002/chin.198616157G. A. ADADUROVA. A. ZHAROV...