Tang PW. Boric acid catalyzed amide formation from carboxylic acids and amines: N-Benzyl-4-Phenylbutyramide. Org Synth 2005;81:262.P Tang,H Krause,A Furstner.Boric acid catalyzed amide formation from carboxylic acids and amines: N-benzyl-4-phenylbutyramide.Organic Syntheses. 2005...
carboxylic acid chloridesspectroscopic dataPingwah Tang*American Cancer SocietyTang, P.; Krause, H.; Furstner, A. Boric acid catalyzed amide formation from carboxylic acids and amines: N-benzyl-4-phenylbutyramide. Org. Synth. 2005, 81, 262; (b) Krikorian, D.; Tarpanov, V.; Parushev, S...
The formation of amide bonds from carboxylic acids and amines is of fundamental importance in nature1. A high proportion of essential chemicals and materials are also constructed from amide bonds, including pharmaceuticals, where amide synthesis is the most frequently conducted reaction2. Traditional ami...
The most desirable amide synthesis, a direct condensation of carboxylic acids with amines, is hindered by the intrinsic acid–base reactivity of the starting materials. The thermal amide bond formation from the ammonium carboxylate salts requires high temperatures5–7, which can be lowered by Lewis ...
carboxylic acidshydrogen bondsmacrocyclesNMRFor 12- and 13-membered macrocycles in which two amide linkages are integrated in the macrocyclic ring systems, the formation of 1:1 host–guest complexes with acetic and benzoic acids has been confirmed by NMR titrations. The complex formation occurs with...
formation in the 19th century, there have been relatively few reports of mechanistic studies, though it is clear that there is not a simple relationship between ease of direct amide formation and the pKaof the carboxylic acid and amine, or whether salt ammonium carboxylate formation is important....
B. DCC C. Et3N D. AlMe3 3. Please choose two popular methods for preparation of Weinreb amide. ( )A.from carboxylic acids or their derivatives B.from alkyl halides C.from primary amides D.from synthetic equivalents containing Weinreb amide functionality 4. Please suggest reagents for the ...
respectively. With recalcitrant amides the use ofnitrous acidcan often be beneficial, the reaction proceeding via an intermediarydiazonium ion. The formation of a diazonium ion significantly increases the rate of the hydrolysis reaction<1990TL3893>. The use of aqueoussodiumperoxide<1975JOC1187>or pot...
10. The use of the compound of claim 1 or 9 in the catalysis of amide bond formation between an amino and a carboxylic acid. 11. A method of forming a compound containing an amide bond, comprising the steps of: reacting an amine, a carboxylic acid, an amide coupling agent and a com...
Jung-Hee OhDep. Appl. Chem.Sejong Univ.Dongyeol LimDep. Appl. Chem.Sejong Univ.ChemInformPark, S.-D.; Oh, J.-H.; Lim, D. A new type of amide formation from thiocarboxylic acid and alkyl azide. Tetrahedron Lett. 2002, 43, 6309-6311...