such as, for example, 2 - pyrrolidone, succinimide, milk acid amide and fatty acid amides, with hydrogen to the corresponding amines can be hydrogenated... I Shuklov,J Schulze,A Brner,... 被引量: 0发表: 2016年 Biocatalytic amidation of carboxylic acids and their antinemic activity The co...
Therefore, reaction selection can influence the success or failure of a candidate molecule to meet a functional objective. The coupling of an amine with a carboxylic acid to form an amide bond is the most popular chemical reaction used for drug discovery1. However, there are many other ways ...
The contribution of Me-N bond cleavage, leading to N -methyl- N -trimethylsilyl derivative Me(Me 3 Si)NCOR and methyl iodide was considerably smaller. Another by-product was the corresponding N -methyl imide MeN(COR) 2 formed by reaction of the initial amide with acyl iodide. The primary ...
delivering the desired products in yields of up to 97%. Importantly, when the nitroarenes bearing nucleophilic functional groups, such free amino (3uu), hydroxy (3al), NH-free indole (3ao), the amide bond formation between carboxylic acid and nitro groups is still predictable. These are cas...
USE:Useful as a preventive and remedy for hyperlipemia such as hyperchlesterolemia, hypertrigricelidemia, hyperphospholipidmia or hyper-fatty- acidmia because of excellent lipid lowering action. PREPARATION:A carboxylic acid derivative expressed by formula II is subjected to condensation reaction with...
Hydrogen bonding between carboxylic acid and amide groups was demonstrated for a series of amides called [n]-semirubins consisting of a dipyrrinone attached to the end of an n-carbon alkanoic acid. Such hydrogen bonding is more effective than the alternative amide to amide or acid to acid ...
This invention provides skin care compositions which include an emollient complex containing a primary moisturizing agent selected from certain carboxylic acid amides and a mucopolysaccharide secondary moisturizing agent. The compositions also include one or more skin-structuring proteins and an astringent agen...
1 Chapter 16 Amines and Amides Amines 2 Amines Amines Are derivatives of ammonia NH 3 . Contain N attached to one or more alkyl or aromatic groups. CH 3 CH 3 CH 3 —NH 2 CH 3 —NH CH 3 —N—CH 3 N H 2 3 Classification of Amines Amines are classified as primary, secondary, or...
The reaction with aldehyde is the one of most concern: RCOH+12O2=RCOOH Since catalysts may promote the oxidation of aldehydes, the presence of carboxylic acid may be a concern for exhaust components downstream of a catalyst. View chapterExplore book Carboxylic Acids Robert J. Ouellette, J. ...
The HAc-modified MnO x catalyst is effective for the selective ammoxidation of 5-hydroxymethylfurfural to hydroxynitrile Full size image To obtain a better understanding of the role of the carboxylic acid in the ammoxidation reaction catalyzed by MnO x , we analyzed the correlation between the ...