Reaction of Indole Carboxylic Acid/Amide with Propargyl Alcohols: [4 + 3]-Annulation, Unexpected 3- to 2- Carboxylate/Amide Migration, and Decarboxylative Cyclization1-Methylindole-3-carboxamidesreact with substituted propargylalcohols to afford lactams by [4 + 3]-annulation and carboxamide group...
However, even the best known systems are limited to a narrow range of amines and require scavenging the reaction water, for example, by large amounts of molecular sieves. (Fig. 1, left)8–13. Therefore, amides are usually synthesized by aminolysis of activated carboxylic acid derivatives, ...
The formation of amide bonds from carboxylic acids and amines is of fundamental importance in nature1. A high proportion of essential chemicals and materials are also constructed from amide bonds, including pharmaceuticals, where amide synthesis is the most frequently conducted reaction2. Traditional ami...
β-Hydroxy alkylamide reacts with carboxylic acid to form an ester much faster than with a normal alcohol. Many suggestions have been made to describe the mechanism of this reaction, but none of them have been proved. It is clear that this reaction cannot be seen as a normal esterification...
HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTEProvided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound ...
Reaction of the 1-tosyl derivative (244) with sodium hydride gave (245). Sign in to download full-size image The alkaline hydrolysis of the 1,4-benzodiazepin-2-one (236) and its 4-oxide resulted in ring opening via amide cleavage. Similarly treatment with methylamine gave (246) which pro...
4,4 ′-(Hexafluoroisopropylidene)- N, N ′-bis(phthaloyl- l-leucine- p-amidobenzoic acid) ( 2) was prepared from the reaction of 4,4 ′-(hexafluoroisopropy... SE Mallakpour,AR Hajipour,S Khoee - 《European Polymer Journal》 被引量: 92发表: 2002年 Synthesis and properties of new...
Solvent Effects, BF 3 Effects, and Trans-Diaxial... The B3LYP density functional studies on the mechanism of the SN2-substitution reaction of methyl halides and epoxides with lithium organocuprates(I), (CH3)... S Mori,E Nakamura,K Morokuma - 《Journal of the American Chemical Society》 被...
A possible explanation of the temperature effect is the endothermic ring-opening reaction of the amide bond (-NHCO-) of the cyclic ε-caprolactam. UV-vis and ATR-IR spectroscopy studies confirmed the presence of open ring structure of ε-caprolactam in membranes. The ECSA and kinetic current ...
Despite the amide formation reaction being one of the key cornerstone reactions in organic chemistry, the direct amide formation is both little used and little explored. Acceptance of the feasibility and general applicability of the reaction depends upon the ability of researchers to bring it into th...