Diffusion is a type of passive transport that involves the net movement of molecules or ions from an area of higher concentration to an area of lower concentration down a concentration gradient. The concentration gradient is the difference in concentration between two points. In biology, diffusion...
L. The cell biology of synaptic plasticity: AMPA receptor trafficking. Annu. Rev. Cell Dev. Biol. 23, 613–643 (2007). Article CAS PubMed Google Scholar Sommer, B., Köhler, M., Sprengel, R. & Seeburg, P. H. RNA editing in brain controls a determinant of ion flow in glutamate...
A.M.G. was financially supported by an advanced European Molecular Biology Organization (EMBO) long-term fellowship. L.T. was supported by the Boehringer Ingelheim Fonds and the Doris Dietschy and Denise Dietschy-Frick-Stiftung. Work in the laboratory of P.S. is supported by the Swiss National...
Communication is a central theme in biology. Consequently, specialized structures have evolved to permit rapid communication among cells, tissues, organs, and physiological systems, thus enhancing the overall function and adaptation of the organism. A prime example is the neuronal synapse. In the ...
It was in the spirit of trying to pass along to a new generation the bitter lessons of the previous generation that informed me as I sat down to discuss what I call “The Original Sin of Molecular Biology”. Comments Offon Teaching Thursday: The Original Sin of Molecular Biology ...
The sea snail Aplysia is among the most widely used ‘model organisms’ in the cellular biology of low-level motor learning and memory. For his contributions to this field of discovery, Eric Kandel [51] shared the 2000 Nobel prize for Physiology or Medicine. Aplysia has two functionally identi...
Furthermore, the flop channels are less responsive to cyclothiazide, and a single point mutation (S750Q) in the alternatively spliced flip/flop eliminates allosteric modulation by cyclothiazide (Partin et al., 1995). Structural Biology of AMPA Receptors Definitive insight into the molecular ...
Cass CE, Young JD, Baldwin SA (1998) Recent advances in the molecular biology of nucleoside transporters of mammalian cells. Biochem Cell Biol 76:761–770 Article CAS PubMed Google Scholar Chandaka GK, Drobny H, Boehm S (2008) Facilitation of transmitter release from rat sympathetic neurons...
In the past half century, computers based on the traditional von Neumann architecture have achieved great progress given their powerful capabilities to deal with computational problems [1]. However, the processors and the memory are physically separated, causing a series of problems such as slow calc...
3a). This is a widely used paradigm that activates robust patterns of sensory-driven neural activity in V1 (refs. 16,17). We found that microglia do not change their level of engulfment as a result of sensory deprivation or stimulation (Fig. 3b,c) but that OPCs significantly heightened ...