The presynaptic terminal contains a complex network of filaments whose precise organization and functions are not yet understood. The cryoelectron tomograp... R Fernández-Busnadiego,B Zuber,UE Maurer,... - 《Journal of Cell Biology》 被引量: 217发表: 2010年 Perikaryal and synaptic localization...
a hypothesis about causal mechanisms, specified formally as a joint probability distribution over some (unobservable, latent or hidden) causes and their (observable, measurable) consequences. What follows is, at every level, undergirded by a generative model that places (strong)...
Analogous to the operation of nerve cell, a spike is generated in the OECN circuit by integration of the current injected into the input terminal (Iin). As shown in Fig.1b, c and f, the integration of the current is carried out by the capacitorCmemwhich increases the voltageVmemgradually,...
Biology 201L: Anatomy & Physiology I with Lab Course Practice 16 chapters | 120 quizzes Ch 1. Biology 201L Labs Ch 2. Anatomy & Physiology Concepts Ch 3. The Tissue Level of Organization Ch 4. Bone Tissue & the Skeletal... Ch 5. The Appendicular Skeleton Ch 6. The Axial Skeleton...
According to Google, it was first initiated in 2011 and considered failure after a decade of struggle.How big science failed to unlock the mysteries of the human brain The Human Genome Project was a massive campaign that turned out to be a great success.It aimed to map all DNA sequences ...
59 They add another level of complexity to the role of KCC2 (at spines) in epileptic seizures: a temporal KCC2 reversal supports the controversial seizure-protecting role of KCC2,24 in particular, when other K+ clearance mechanisms are compromised (e.g., disrupted astrocytic syncytium60). ...
The nectin-afadin system is a novel cell-cell adhesion system that organizes adherens junctions cooperatively with the cadherin-catenin system in epithelia... Mizoguchi,A. - 《Journal of Cell Biology》 被引量: 582发表: 2002年 Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immun...
To elucidate the nature of signals that control the level and spatial distribution of mRNAs encoding acetylcholine receptor (AChR), alpha-, beta-, gamma-, delta- and epsilon-subunits in muscle fibers chronic paralysis was induced in rat leg muscles either by surgical denervation or by different ...
“refractory period” of 1μs is considered, as in biology36. Every neuron can be equipped with a further synaptic device (named “state”) which directly affects the firing threshold VTHduring the learning activity, Fig.2a. Thus, synaptic and internal RRAM devices constitute a proper framework...
At a more general level, it will be interesting to determine the extent to which PNN deficits are a common hallmark of neurodegenerative diseases, and furthermore how this relates to differential microglial phenotypes. It is also possible that some of the deleterious effects of diseased microglia ...