Asynapseis defined as the major mode of communication between neurons or between neurons and another kind of target, such as muscle cells. Neurons are the major cell types of the nervous system, which corresponds to the brain, spinal cord, and all the nerves in the body. Synapses are spaces...
Lack of synapsin function, either due to genetic disruption or to antibody microinjection, impairs clustering of SVs at synapses with the exception of the pool of vesicles most close to the presynaptic plasma membrane9,10,11,12. Until now, however, whether synapsin is sufficient to organize ...
Synapses are the structural elements of the neuronal network through which cellular communication occurs. A prerequisite for understanding synaptic information transfer is the identification of the various components of the synaptic machinery. Recently, different molecular genetic techniques have been developed...
Early changes in the pathogenesis in Ppt1−/− mice involve breakdown of axons and synapses [34], and PPT1 has been implicated in the recycling of synaptic vesicles. This was based on the observations of a reduced total and readily releasable synaptic vesicle pool size, and persistent membr...
We will also determine the structural domain that mediates Lqf function at synapses. In the 2nd Aim, we will determine the synaptic role of Lis1 and the genetic and biochemical relationship between Lqf and Lis1. Finally, we propose to characterize one of the novel lqf modifiers to further ...
Age-related impairment of neurovascular coupling (NVC; “functional hyperemia”) is a critical factor in the development of vascular cognitive im
Figure 1. Monoclonal Antibody nc82 Labels a Component of the Presynaptic Active Zone at All Types of Larval Neuromuscular Synapses (A and B) Confocal images of neuromuscular synaptic boutons (type Ib) in wild-type Drosophila larvae immunostained with MAB nc82 (red) and with antisera against Dyn...
Fig. 1: Sexually dimorphic perception of tail mechanosensation at the sensory level. aPredicted connectivity of the circuit for tail mechanosensation27,29. Chemical synapses between sensory (triangles), inter- (hexagons) and motor (circles) neurons are depicted as arrows. Thickness of arrows correlat...
(neurons and Schwann cells), synapses in synaptic plasticity regions, and neural stem cells (subventricular zone) [44,114]. In brain, the rapid changes of sialylation in cell-surface may occur physiologically, usually induced by the transfer of NEU1 or NEU4 to the cell surface [115]. Acute...
heart rate variability (HF-HRV), but rather the involvement of the ACC (Lane et al., 2009). It is also important to note that a recent study displayed stronger connectivity in the aMCC-hypothalamus network in relation to lower skin conductance level, emphasizing therefore the involvement of aM...