Although the mechanism of long-term memory is not known, it is believed that long-term memory must at some level require stable changes in the molecular components of the neuronal synapse, perhaps mediated by local regulation of protein synthesis (Darnell, 2003). The cytoplasmic polyadenylation ele...
Synapse Definition & Function Nerves: Formation, Structure & Organization Receptor Site in Psychology | Definition, Importance & Types Neurons Lesson Plan Neurobiology | History, Definition & Scope Nervous Tissue: Cell Types & Stimuli Response Nervous Tissue Lesson for Kids Using a Microscope to Observe...
Cheryl has taught veterinary and medical students for over 20 years and has a DVM and PhD degree in reproductive biology. Cite this lesson Neurons are electrically excitable cells located in the central and peripheral nervous systems that receive and transmit information. The cellular contents and ...
Interestingly, changes in the activity of tricarboxylic acid (TCA) cycle enzymes and the electron transport chain (ETC), have recently been reported to affect energy production and thus synapse loss in AD models62. Given that succinate dehydrogenase represents both a critical enzyme in the TCA ...
Such a unique quaternary structure has only been observed for soluble and synapse membrane-anchored cholinesterases [62]. Knowledge of this quaternary structure will be further useful for developing strategies to improve the conformational stability of the enzyme and its pharmacokinetic properties. These ...
Synapse 59, 472–479 (2006). CAS PubMed Google Scholar Chowdari, K. V. et al. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum. Mol. Genet. 11, 1373–1380 (2002). CAS PubMed Google Scholar Morris, D. W. et al. Confirming RGS4 as a susceptibility gene...
Synapse Illustration by Nrets [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0/)]Neurons are some of the most important cells in the body. This is because they are involved in cell communication that, in turn, allows an organism to function as it should in its environment....
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A. The vital role of constitutive GPCR activity in the mesolimbic dopamine system. Transl. Psychiatry 4, e361 (2014). Article CAS PubMed PubMed Central Google Scholar Sando, R. & Sudhof, T. C. Latrophilin GPCR signaling mediates synapse formation. eLife https://doi.org/10.7554/eLife....
As discussed earlier, the morphology of the dendritic spine directly correlates with its level of AMPA receptor expression, implying that these actin-binding proteins may regulate the strength of a synapse. A direct link between spine morphology and an actin-regulatory protein is provided by the ...