(b) Diagram of a gap junction showing how hexamers of the subunit protein, connexin, in each membrane form a channel crossing the extracellular gap. (c) Immunofluorescence stain of ventricular myocytes with an anticonnexin 43 antibody. Intercalated discs and some lateral appositions are labeled. ...
Top, the image of a dendritic spine has been enlarged and overlapped with a diagram showing a schematic organization of the network of proteins in the PSD. Major families and certain classes of PSD proteins are shown. Some interactions between them are schematically indicated. The PSD-95 Family...
While GMV is a complex measure that encompasses glia, vasculature and neuronal dendritic and synapse volumes, longitudinal studies show a lifetime trajectory of GMV loss106,107 that temporally correlates with neuropathological studies of dendritic spine loss due to increased synapse pruning during adole...
e, Venn diagram showing the overlap between Year18_22 samples in this study and the human PSD proteomes published in Roy et al., 2017 and Bayés et al., 2011. f, UpSet plot describing the number of identified proteins and their overlaps at each age group. g, PCA plots of the samples...
a–eOVA-loaded RMA-s target cells were mixed with OT-1 CTLs in the presence of LFA1-blocking antibody (αLFA-1) or isotype control. PMA/Iono was applied to some samples in order to drive TCR-independent CTL activation.aSchematic diagram of the experimental design.bTarget cell killing, me...
Influences of glia on synapse development. Diagram illustrating the different effects of glia (green) on the development of synaptic connections between pre- (yellow) and postsynaptic (grey) partner neurons. Some neurons form synapses in the absence of glial cells (a), whereas others do not (b...
Schematic diagram of an axodendritic synapse for each class of GC.(A)Time-course analysis of two elements during the maturation of the first glutamatergic contact onto newborn GCs. The NMDAR/AMPAR ratios are shown in red. Functional release sites (blue) are indicated as either single or multip...
a Schematic diagram of the experimental design. b Target cell killing, measured 4 h after CTL-target cell mixing (N = 2 replicate experiments). c Lamp1 exposure (degranulation), measured 90 min after CTL-target cell mixing (N = 4 replicate experiments). d CD69 expression, ...
and Hoechst.gVenn diagram capturing number and distribution of proteins identified in sorted MF synaptosomes and P2 synaptosomes by LC–MS/MS in three independent experiments (10–12 mice per experiment).hRelative distribution of proteins detected in sorted MF synaptosomes and P2 synaptosomes. Significa...
(A) Diagram of KIBRA and WWC2 interaction domains and phosphorylation sites. (B and C) Analysis of WWC2 gene expression from the Allen Institute for Brain Science Cell Types Database (RNA-seq data, mouse whole cortex and hippocampus-10× Genomics with 10× Smart-Seq Taxonomy); https://por...