Top, the image of a dendritic spine has been enlarged and overlapped with a diagram showing a schematic organization of the network of proteins in the PSD. Major families and certain classes of PSD proteins are shown. Some interactions between them are schematically indicated. The PSD-95 Family...
ATimeline of CORT administration and behavioral assays (temporal object recognition “TOR” and sucrose preference test “SPT”).BSchematic diagram of TOR assay (left), with an image of 3D printed objects used for assay (right).CQuantitation of sucrose preference of wildtype and C3−/−contr...
e, Venn diagram showing the overlap between Year18_22 samples in this study and the human PSD proteomes published in Roy et al., 2017 and Bayés et al., 2011. f, UpSet plot describing the number of identified proteins and their overlaps at each age group. g, PCA plots of the samples...
(A) Venn diagram showing the overlap of significantly differentially expressed genes (adjusted p-value < 0.1) in APP-PS1 + PBS versus WT + PBS and APP-PS1 + anti-CD8 versus APP-PS1 + PBS animals. (B) Volcano plot of significantly differentially expressed genes and their respective fold ...
Influences of glia on synapse development. Diagram illustrating the different effects of glia (green) on the development of synaptic connections between pre- (yellow) and postsynaptic (grey) partner neurons. Some neurons form synapses in the absence of glial cells (a), whereas others do not (b...
the holes concentration in the P3HT-NF/PDMS semiconductor channel keeps the original value. It can also be seen from the corresponding energy band diagram that the vacuum energy level of the Ti/Au electrode and the P3HT-NF/PDMS semiconductor is the same and the conduction band and valence ...
(right) Percentage of proteins included in each term.gandhVenn diagram illustrating the overlap of the proteins classified into DDP, DIP, Late DDP, and Late DIP. Total proteins (g) or proteins of Synaptogenesis Signaling Pathways (h) are described. Source data are provided as a Source Data ...
when examined on a neuron-by-neuron basis, more diverse patterns of synapse change are revealed. These observations may explain some discrepancies among previous studies of the SHY, as these single-neuron synaptic dynamics would not be captured by population-level, single-time-point snapshots of sy...
on the basis of the expression level of activity marker genes (Methodsand Extended Data Fig.10d). The PSI of E31 (d, middle) or E32 (d, right) for individual neurons, and the cumulative probability of all neurons for E31 (e) or E32 (f) are shown. Statistical analysis was performed ...
FIG. 2Bis a block diagram illustrating signal processing of a dynamic synapse with multiple internal synaptic processes. FIG. 3Ais a diagram showing a temporal pattern generated by a neuron to a dynamic synapse. FIG. 3Bis a chart showing two facilitative processes of different time scales in a...