We present a systems strategy that facilitated the development of a molecular signature for glioblastoma (GBM), composed of 33 cell-surface transmembrane proteins. This molecular signature, GBMSig, was developed through the integration of cell-surface proteomics and transcriptomics from patient tumors in...
Multinucleated osteoclasts, essential for skeletal remodeling in health and disease, are formed by the fusion of osteoclast precursors, where each fusion event raises their bone-resorbing activity. Here we show that the nuclear RNA chaperone, La protein has an additional function as an osteoclast fus...
This is in contrast to, for example, G protein-coupled receptors of the nervous system. These receptors traverse the membrane seven times, and the ligand binding sites are more intimately associated with transmembrane segments and difficult to isolate. Show moreView chapter Chapter Non-Adhesive ...
5D). The HeLa cells were stained with a lipophilic membrane dye (Dil) that inserts into the cell membrane interior, while the HEK cells labeled a transmembrane receptor protein. Both cell types and labeling methods generated similar results, which illustrates that the alkanethiol-membrane ...
ADAMs cleave a variety of transmembrane proteins, including APP, within their extracellular domains, resulting in shedding of the ectodomain fragment [4]. Multiple receptor ligands, as well as direct activators of protein kinase C (PKC), stimulate ectodomain shedding of APP and other proteins [6]...
G protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins belonging to a large family of cell-surface receptors involved in many intracellular signaling cascades. Despite GPCRs lack intrinsic tyrosine kinase activity, tyrosine phosphorylation of a tyrosine kinase receptor (RTK) occurs...
This article reviews various effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility, including protein adsorption, cell adhesion, cytotoxicity, blood compatibility, and tissue compatibility. Understanding these aspects of biocompatibility is important to ...
[翻译原文]Development of a placement time estimator function for a turret style surface mount placement machine 热度: Teneurins, a transmembrane protein family involved in cell communication during neuronal development 热度: The VirE3 protein of Agrobacterium mimics a host cell function required ...
The invention also concerns the uses of said antibodies for selecting cells expressing at their surface said protein. Said isolated protein has a structure (a) comprising an extracellular domain located between positions 21 and 152, five transmembrane domains located between positions 153 and 295 and...
of said antibodies for selecting cells expressing at their surface said protein. Said isolated protein has a structure (a) comprising an extracellular domain located between positions 21 and 152, five transmembrane domains located between positions 153 and 295 and a cytoplasmic domain located between ...