2. The first use of a therapeutic protein developed was insulin, used as a therapy for diabetes mellitus3. Since then, over 200 protein-based compounds have been approved for clinical use and over 250 proteins are currently in various stages of clinical evaluation4,5. While...
The advantage of using such systems is that the viruses contain few structural proteins, including usually one (VSV:G protein) or two (Sindbis: E1 and E2) integral membrane glycoproteins and in some cases, an internal peripheral membrane protein (VSV:M protein). In contrast, an average ...
The advantage of using such systems is that the viruses contain few structural proteins, including usually one (VSV:G protein) or two (Sindbis: E1 and E2) integral membrane glycoproteins and in some cases, an internal peripheral membrane protein (VSV:M protein). In contrast, an average ...
Staining was present in the cytoplasm but there was often also stronger peripheral labeling in the region of the cell membrane. Table 2. Immunostaining of normal hematopoietic tissues for transmembrane adaptor proteins Empty CellLATLIMETRIMNTALPAGSIT Tonsil/lymph node Lymphoid follicles Germinal ...
Fig. 1: INM proteins use the NPC’s peripheral channels to enter the nucleus. aThe two suggested NPC-dependent transport models for INM proteins (blue). (i) The lateral diffusion-retention model suggests that INM proteins with small luminal domains (blue) may freely diffuse through ~10 nm...
About 30% of genes code for membrane proteins, which are involved in a wide variety of crucial biological functions. Despite their importance, experimentally determined structures correspond to only about 1.7% of protein structures deposited in the Protein Data Bank due to the difficulty in crystalliz...
For instance, if detection of liver is desired, it may not matter whether the selective polynucleotide is expressed in other tissues, as long as it is not expressed in cells normally present in blood, e.g., peripheral blood mononuclear cells. Starting from the selective polynucleotide, a ...
1992. Internalization of glycosyl-phosphatidylinositol (GPI)-anchored lymphocyte proteins II. GPI-anchored and transmembrane molecules internalize through distinct ... A Bamezai,VS Goldmacher,KL Rock - 《European Journal of Immunology》 被引量: 14发表: 2010年 Hannan, L. A. & Edidin, M. Glycosyl...
Membrane proteins, comprised of integral and peripheral membrane proteins, are replete with intrinsic biochemical and biophysical properties that are crucial in manifold biological functions [49], such as signal transduction [50] and enzymatic activity [51]. Integral membrane (IM) proteins, which compri...
tolerance to metal stress relies on allocation and detoxification strategies at organ, tissue and cell level8. Increased TME tolerance can be achieved through allocation to e.g. older foliage organs12and/or peripheral and physiologically less active tissues in the leaf vein13, leaf blade14, and ...