S., Klutsch, D., Schaffner-Barbero, C., and Hamoen, L. W. (2015). Transmembrane protein sorting driven by membrane curvature. Nat. Commun. 6, 8728. doi: 10.1038/ncomms9728Strahl, H. et al. Transmembrane protein sorting driven by membrane curvature. Nat Commun 6, 8728 (2015)....
Membrane Proteins Simen Hermansen, ... Jack C. Leo, in Advances in Protein Chemistry and Structural Biology, 2022 1 Introduction Transmembrane proteins fall into two major classes. The transmembrane domains of the more abundant, and therefore more familiar, class consist of hydrophobic α-helices. ...
Thermosensing via transmembrane protein–lipid interactionsdoi:10.1016/j.bbamem.2015.04.005MembraneproteinTemperaturesensingTransmembranesignalingLipidinteractionCell membranes are composed of a lipid bilayer containing proteins that cross and/or interact with lipids on either side of the two leaflets. The ...
The protein folding in membranes is complicated because the lipid interior of the membrane is non-polar, thus making no separation of electrical charges. Therefore, a stable protein must place non-polar, water-fearing residues on its surface and pack its polar, water-loving ones inside, just o...
The core of the retrovirus Murine leukemia virus (MLV) consists of the Gag precursor protein and viral RNA. It assembles at the cytoplasmic face of the cell membrane where, by an unclear mechanism, it collects viral envelope proteins embedded in the cell membrane and buds off. The C-terminal...
of cell signaling pathways. Introduction The sterol regulatory element-binding protein (SREBP) was the first described example of a membrane anchor acting to maintain transcription factors in a dormant state in the cytosol until their release is triggered by RIP1. RIP starts with cleaving off the ...
Influenza A M2 protein is a small, 97 amino acid, single-pass transmembrane protein, which is known to oligomerize forming a tetrameric proton-selective channel (Fig. 1A)1–3. This protein plays an essen- tial role in viral adjustment and successful replication in the host cell; ...
These nonstructural viral proteins induce efficient cell-cell rather than virus-cell membrane fusion. We analyzed the lipid environment in which the reptilian reovirus p14 FAST protein resides to determine the influence of the cell membrane on the fusion activity of the FAST proteins. Topographical ...
membrane scaffolding proteins (MSPs). Thus, we aim to create two types of nanocarriers, tmSCF proteoliposomes, and nanodiscs to deliver tmSCF effectively to ischemic sites (Fig.1A). Transmembrane stem cell factor (tmSCF) protein was first harvested and purified as described in “Methods” ...
NMR structure and localization of a large fragment of the SARS-CoV fusion protein: implications in viral cell fusion Biochim. Biophys. Acta, 17 (2017), pp. 30312-30317 Google Scholar [75] D. Beinert, L. Neumann, S. Uebel Structure of the viral TAP-inhibitor ICP47 induced by membrane as...