Obverse Cover : The cover image is based on the Research Article β‐Strand twisting/bending in soluble and transmembrane β‐barrel structures by Nobuaki Kikuchi et al., DOI: 10.1002/prot.25576 .doi:10.1002/prot.25626Nobuaki KikuchiDepartment of Bioinformatics Soka University Tokyo JapanKazuo ...
Ewerling, A., Maissl, V., Wickstead, B., and May-Simera, H.L. (2023).Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes. iScience 26, 106410. 10.1016/j.isci.2023.106410. Messelodi, D., Strocchi, S., Bertuccio, S...
Induction of apoptosis is due to the absence of speci- fic interactions between transmembrane receptors of the integrin family and extracellular matrix proteins [2]. The triggering of apoptosis requires the activation of specific enzymes called caspases [3], differently associated as inactive form with...
It is caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene, which encodes an apical membrane anion channel that is required for regulating the volume and composition of epithelial secretions. The most common CFTR mutation, present on at least one allele in >90% of CF ...
Description: This H5C6 monoclonal antibody reacts with human CD63, a type III member of the tetraspanin family of transmembrane proteins. CD63 is expressed intracellularly on lysosomes, endosomes, and granules of resting platelets and basophils. However, cell surface expression of CD63 ca...
and transmembrane domain-containing proteins termed INM proteins. Nuclear pore complexes (NPCs), the gateways for all molecules that enter and exit the nucleus, are embedded in the NE1. Thus, an understanding of their function and the regulatory mechanisms of their assembly is a prerequisite for ...
Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim. Biophys. Acta 1993, 1151, 201–215. [CrossRef] 36. Ohanian, M.; Kantarjian, H.M.; Ravandi, F.; Borthakur, G.; Garcia-Manero, G.; Andreeff, M.; Jabbour, E...
The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is...
Electrophysiological effects of diprafenone, a dimethyl congener of propafenone on guinea-pig ventricular cells. 1. The effects of diprafenone and propafenone on transmembrane action potential were examined and compared in papillary muscles and single ventricular myoc... I Kodama,R Suzuki,H Honjo,....
They are also overexpressed in endothelial cells of the tumor vasculature where they promote cell migration (Avraamides et al. 2008; Desgrosellier and Cheresh 2010). The Arginine-Glycine-Aspartic acid (RGD)-recognising αVβ3,αVβ5 and α5β1 heterodimeric transmembrane receptors have been ...