Non-alcoholic fatty liver disease (NAFLD), due to aberrant lipid metabolism, has become an increasingly prevalent health problem worldwide1. Anomalous lipid metabolism plays a crucial role in the progression of NAFLD, attacking hepatocytes2. Excessive accumulation of triglyceride (TG) in hepatocytes, ...
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing . EMBO Rep . 2008; 9 :273-9Haindl M, Harasim T, Eick D, Muller S (2008) The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is ...
www.nature.com/scientificreports OPEN received: 17 June 2016 accepted: 26 October 2016 Published: 17 November 2016 SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease Yuhan Liu1,*, Fudong Yu2,*,Yan Han1, Qing Li1, Zhujun...
Mammalian cells express six SENPs, designated SENP1–3 and SENP5–7. All are cysteine proteases and have catalytic triads (Cys–His–Asp) in a conserved protease domain. They differ in their subcellular localization, substrate specificity, and selectivity for SUMO precursor processing versus ...
NF-kappaB induction of the SUMO protease SENP2: a negative feedback loop to attenuate cell survival response to genotoxic stress Mol. Cell. (2011) T.Yamadaet al. Dynamin-related protein 1 deficiency leads to receptor-interacting protein kinase 3-mediated necroptotic neurodegeneration ...
3–5 .Mdm2isalsoself- ubiquitinatedanddegraded.Here,weidentifiedanovel cascadefortheincreaseinp53levelinresponsetoDNA damage.AnewSUMO-specificprotease,SUSP4,removed SUMO-1fromMdm2andthisdesumoylationledtopromotion ofMdm2self-ubiquitination,resultinginp53stabilization. ...
西亚试剂:SUMO-Specific Protease 1 Is Critical for Early Lymphoid Dev SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation Thang Van Nguyen, Pornpimon Angkasekwinai, Hong Dou, Feng-Ming Lin, Long-Sheng Lu, Jinke Cheng, Y. Eugene Chin, Chen...
SUMO-SpecificProtease1IsCriticalforEarlyLymphoid DevelopmentthroughRegulationofSTAT5Activation ThangVanNguyen 1,3 ,PornpimonAngkasekwinai 2,4 ,HongDou 1 ,Feng-MingLin 6 ,Long- ShengLu 6 ,JinkeCheng 6 ,Y.EugeneChin 5 ,ChenDong 2,3 ,andEdwardT.H.Yeh ...
关键字: Sentrin;specific ;protease 2;Axam2;SMT3;specific ;isopeptidase 2;Sentrin; 公司简介 上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品:试剂盒,ELISA试剂盒,抗体,重组蛋白,血清,胎牛血清,细胞,原代细胞 细胞培养试剂,常用生化试剂。 成立...
Together, these ABPs demonstrate the versatility and specificity of our synthetic SUMO platform for invitro and invivo characterization of the SUMO protease family.doi:info:doi/10.1002/anie.201803483Mulder, Monique P. C.Merkx, RemcoWitting, Katharina F....