6.3 Pharmacology and mechanism of action The efficacy of sulphadoxine for the treatment of human malaria was first reported in 1964 [1]. Soon thereafter it was found that potentiation took place when sulphadoxine was combined with pyrimethamine for treatment of malaria and monotherapy was abandoned...
The rational drug design allows the development of single hybrid molecules with dual functionality and/or targets, with the same or distinct mechanism of action from parent drugs. Moreover, a new generation of hybrids, instead of combined drugs, has the potential advantage of a lower risk of ...