Mechanism of Action: Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for th...
Mechanism of action of silver sulfadiazine appears to differ from sulfadiazine and silver nitrate; acts on cell membrane and cell wall to produce bactericidal effects. Wide spectrum of activity against most burn pathogens, including species of both gram-positive and gram-negative organisms, including ...
Due to the mechanism of action of antibiotics and bacterial evolution, the problem of antibiotic resistance is complex and possibly impossible to overcome [9]. However, some methods can be used to reduce the emergence and impact of resistance. In the treatment of bacterial infections, combining ...
21. Jagdale SC, Kothekar PV (2020) Development of emulgel delivery of mupirocin for treatment of skin infection.RecentPat Antiinfect Drug Discov15(2): 137–56 22. Khoshnood S, Heidary M, Asadi A et al (2019) A review on mechanism of action, resistance, synergism, ...
Cyclosporine Concurrent use of sulfadiazine and cyclosporine decreases cyclosporine concentrations Spes et al (1992). The mechanism is unknown. Phenytoin and fosphenytoin Sulfadiazine and certain other sulfonamides inhibit phenytoin clearance and increase its half-life Hansen et al (1979). Typhoid vaccine ...
The results were verified in vitro on mature mixed bacterial voice prosthesis biofilms from patients, and the possible mechanism of action was explored. Results: Silver sulfadiazine decreased the number of bacterial colonies on mature mixed bacterial voice prosthesis biofilm, significantly inhibited the ...
The mechanism of action of silver sulfadiazine (AgSD) against Pseudomonas aeruginosa was investigated by use of the isotopes, 110Ag and 35S. AgSD was found... SM Modak - 《Biochemical Pharmacology》 被引量: 395发表: 1973年 Silver-nylon: a new antimicrobial agent. Silver-impregnated cloth and...
utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell wall to produce its bactericidal ...
Mechanism of silver sulfadiazine action on burn wound infections. The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. Silver, but not sulfadiazi... CL Fox,SM Modak - 《Antimicrob Agents Chemother》 被引量: 315发表: ...
Fig. 1.Antibacterial mechanism of chitosan, metal-based nanoparticles and carbon-based composites. Metallicoxidenanoparticles, including zinc oxide (ZnO) and titanium dioxide (TiO2), have been applied as inorganic antibacterial materials, and the action mechanisms are presented inFig. 1. Among various...