[pharmacodynamics] The mechanism of action is to interfere with the synthesis of nucleic acids required by pathogenic microorganisms, so that the bacteria lack nutrition and stop growth, development and reproduction. The hemolytic Streptococcus, Staphylococcus and meningococcus have inhibition and killing...
MECHANISM OF ACTION : Estrone sulfatase inhibitor. Estrone sulfatase inhibition of (Ia) was measured in female Sprague-Dawley rats (40-50 g) using the method described by Wakeling et al in Endocrinology:99:447-453 (1983). (Ia) had an IC50 of 16 picomolar with no observed estrogenic ...
Mechanism of Action. The antimicrobial effects of sulfonamides are due to inhibition of dihydropteroate synthase, a bacterial enzyme required to produce tetrahydrofolate. The mechanism of toxicosis relates to the physiochemical properties of these drugs, their actions on normal bacterial flora, or the ...
The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to paraaminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determin...
2Mechanism of Action The exact mechanism whereby EETs inhibit platelet aggregation has not been established. In human platelets, inhibition of aggregation by EETs was not associated with a decrease in the production of the proaggregatory, thromboxane (TX) A2(Fitzpatrick et al., 1986). However, ...
相关类别: Interferes with DNA SynthesisSpectrum of Activity;L - ZAntibiotics;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics N-SAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Mechanism of Action;Sulfonamides;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Seleniu...
Mechanism of Action: Sulfadoxine is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxine target...
Poultry Farming: In the field of poultry farming, sulfadimethoxypyrimidine is used as a feed additive to prevent and treat coccidiosis, a parasitic disease that affects the intestinal tract of birds. The mechanism of action in this context involves inhibiting the growth and reproduction of the cocc...
probenecid has been used for decades for the treatment of gout. The mechanism of action of the drug isinhibition of a renal tubular transporter, thereby facilitating the excretion of the disease causative uric acid by blocking reuptake (5, 26, 37). ...
MECHANISM OF ACTION : Estrone sulfatase inhibitor. Estrone sulfatase inhibition of (Ia) was measured in female Sprague-Dawley rats (40-50 g) using the method described by Wakeling et al in Endocrinology:99:447-453 (1983). (Ia) had an IC50 of 16 picomolar with no observed estrogenic ...