Only a minority of patients derive long-term clinical benefit from anti-programmed cell death protein 1 (anti-PD-1) or anti-programmed death-ligand 1 (anti-PD-L1) monoclonal antibodies. The presence of tertiary lymphoid structures (TLSs) has been associa
In some embodiments, segmentation comprises a two tiered approach (2-D segmentation, followed by 3-D segmentation) based on adaptation of the level set framework to the particular conditions of lymph node segmentation.Oranit DrorGuy Engelhard
LymphnodeBoneWe report eight patients in whom bones of the cervical spine or cervical ribs were clinically mistaken for jugular chain or supra-clavicular lymphadenopathy, respectively. Each was referred for fine-needle aspiration by an experienced surgeon, oncologist, rheumatologist, or otolaryngologist....
of cancers and are usually associated with positive patient outcomes. However, TLS differ vastly in cellular composition and location within tissue types. In this review, we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors...
lymph node (lymphaden/o) small, spherical bodies composed of lymphoid tissue aorta (aort/o) largest artery in the body ventricle (ventricul/o) lower chamber of the heart vessel (angi/o) tubelike structures that carry blood or other fluides plasma (plasm/o) clear, straw-colored, liquid por...
Apoptosis: A Review of Programmed Cell Death Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System Normal Structure, Function, and Histology of the Spleen Normal Structure, Function, and Histology of the Bone Marrow Normal Structure, Function, and Histology of Lymph Node...
Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the tumor microenvironment (TME). However, the function and mechanisms of tumor...
Tissue engineering is the process by which biological structures are recreated using a combination of molecular signals, cellular components and scaffolds. Although the perceived potential of this approach to reconstruct damaged or missing tissues is seemingly limitless, application of these ideas in vivo...
Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma In this communication, the contribution of stromal, or non-hematopoietic, cells to the structure and function of lymph nodes (LNs), as canonical secondary...
Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma as a model, here we analyse single-cell transcriptomes of 343,829 cells fr