In the way of the lymphatic vessels there are ganglial-like structures called lymph nodes that contain many cells of the immune system. These cells filter impurities and destroy microorganisms and cellular wastes. The lymphatic vessels drain to two major lympha...
using a case study of breast cancer from the popular database METABRIC13. The goal of this work is to help improve the available analysis pipeline, in a more systematic and efficient way, in the identification and analysis of driver genes in future studies. Moreover, in recent years,...
B-cell lymphoma (BCL) accounts for a considerable number of cancer cases1, with more than 300,000 new patients per year worldwide2. Diffuse large B-cell lymphoma (DLBCL) is the most common form of BCL. Patients with this aggressive disease are often diagnosed at advanced stages3. Next-gen...
An in vivo teratoma showed that the iPSC-like cells generated multiple germ layers tissues but preferred to generate endodermal ductal structures. DNA methylation is another critical epigenetic change. However, the reprogramming of cancer cells into iPSCs shows that only about 50% of cancer-...
we found that genes with putative roles in bone regulatory processes were more highly connected than all other genes (P = 3.5 × 10−4,P = 1.7 × 10−2, andP = 2.9 × 10−5for combined, male, and female network sets, respectively), indicating the structures of the...
a subset of patients, and the mechanisms at the basis of therapeutic resistance are poorly known3. A number of studies have initially focused on the mutational load of the tumor as well as on quality of the cells infiltrating the tumor microenvironment, and revealed that increased mutational ...
Thus, it is now important to find methods able to evaluate the sensitizing potential of mixtures. This is a problematic task in existing methods. The in vivo local lymph node assay (LLNA), assessing sensitization to chemicals in mice has been used for assessment of some essential oils. It ha...