RNA structure is thought to play a central role in many cellular processes, including transcription initiation, elongation and termination, mRNA splicing, and retroviral infection of eukaryotic cells. Perhaps the most striking example of RNA structure being critical ...
RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcriptome-wide analysis of RNA secondary structure
12,13]. An important impact of RNA editing is its ability to challenge the central dogma of biology. When RNA editing takes place in the coding sequence (CDS) region of an mRNA, where an I is recognized as a G or
RNA is involved in many cellular processes such as control of gene expression, catalysis of various substrates, scaffolding of complex assemblies, and molecular chaperoning15. Its ability to act as a hub of cellular networks is at the centre of an active research field and has already led to t...
Furthermore, the non-coding sequence extending across and between the 3' ends of these genes is also very well conserved (Figure 1B). The most striking conservation is located at the extreme 3' end of TRα1 mRNA, in which a sequence of 140 bp is almost identical to that in the rat ...
mRNA: The Relation of Structure to Function. Progress in Nucleic Acid Research and Molecular Biology, Volume 19.Cohn, E. Waldo EVollin
mRNA and protein expression of nitric oxide synthase and adrenoceptor alpha 1 in young and old rat penile tissues To investigate alterations of neuronal structure and the mRNA expression of nitric oxide synthase (NOS) and adrenoceptor alpha 1 in young and old rat penil... R Dahiya,A Lin,ME ...
a target in the mRNA. Other examples include snoRNAs, which modify ribosomal RNA [3],signal recognition particleRNAs [4],cis-acting regulatory elements, and piRNAs [5], a novel class of ncRNAs whose function is still unclear. It is likely that only a small fraction of regulatory RNAs has...
RNA structure is intimately connected to each step of gene expression. Recent advances have enabled transcriptome-wide maps of RNA secondary structure, called ‘RNA structuromes’. However, previous whole-cell analyses lacked the resolution to unravel th
Structural analysis revealed that Ebola virus L possesses a filovirus-specific insertion element that is essential for RNA synthesis, and that VP35 interacts extensively with the N-terminal region of L by three protomers of the VP35 tetramer. Notably, we captured the complex structure in a ...