We report a novel loss-of-function mutation in the TLDc domain of the humanOXR1gene, resulting in early-onset epilepsy, developmental delay, cognitive disabilities, and cerebellar atrophy. Patient lymphoblasts show impaired cell survival, proliferation, and hypersensitivity to oxidative stress. These ...
RNA Structure Has a Biological Role RNA structure is thought to play a central role in many cellular processes, including transcription initiation, elongation and termination, mRNA splicing, and retroviral infection of eukaryotic cells. Perhaps the most striking exam...
The part of the mRNA transcript 3′ to the protein coding region that constitutes the main functional microRNA-targeting region. KEGG (Kyoto Encyclopedia of Genes and Genomes). Database of biological pathways commonly used as a resource for understanding high-level functions of a biological system...
The part of the mRNA transcript 3′ to the protein coding region that constitutes the main functional microRNA-targeting region. KEGG (Kyoto Encyclopedia of Genes and Genomes). Database of biological pathways commonly used as a resource for understanding high-level functions of a biological system...
M. et al. mRNA structure determines specificity of a polyQ-driven phase separation. Science 360, 922–927 (2018). CAS PubMed PubMed Central Google Scholar Ries, R. J. et al. m6A enhances the phase separation potential of mRNA. Nature 571, 424–428 (2019). CAS PubMed PubMed Central...
Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal ligaments. Matricellular proteins are a nonstructural family of extracellular matrix (ECM) proteins that re
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To validate our rG4-seq, we mapped RT stops on the mRNA of SUPPRESSOR OF MAX2 1-LIKE5 (SMXL5) which contains a G-rich region with RG4 folding potential identified recently [9]. We found a strong RT stalling at the 3′end of this G-rich region where the coverage dropped in the ...
Rocaglamide A (RocA), an antitumor heterotricyclic natural compound, has been shown to inhibit translation initiation of a large group of mRNA species by clamping eIF4A onto poly-purine motifs in the 5′ UTRs. However, reanalysis of previous ribosome profiling datasets reveals an unexpected shift...
How does sub-cellular localization affect the fate of bacterial mRNA? Curr. Genet. 62, 687–690 (2016). CAS Google Scholar Hay, I. D., Belousoff, M. J., Dunstan, R. A., Bamert, R. S. & Lithgow, T. Structure and membrane topography of the Vibrio-type secretin complex from the...