- 《Cell Growth & Differentiation the Molecular Biology Journal of the American Association for Cancer Research》 被引量: 549发表: 1994年 VIP: Molecular biology and neurobiological function In the mammalian brain, a major regulatory peptide is vasoactive intestinal peptide (VIP). This 28 amino acid...
In this Review, we focus on the regulation and function of non-m6A modifications in eukaryotic mRNA, including pseudouridine (Ψ), N6,2′-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), inosine, 5-methylcytidine (m5C), N4-acetylcytidine (ac4C), 2′-O-methylated nucleotide (Nm) and...
Cellular IRESs tend to integrate or interact with RNA chaperones, upstream open reading frames and/or G-quadruplex structures for function. The initiation factor eIF3 can have a specialized function in translation by directly binding to structured or chemically modified 5′ UTRs in target mRNAs to ...
3'端poly(A)尾巴对于mRNA的翻译来说发挥着至关重要的作用,它可以保护mRNA不被降解,增加mRNA的稳定性,提高翻译效率。那大家知道poly(A)尾是如何促进翻译并控制mRNA的稳定性的吗?今天菌菌分享一篇在《Nature Reviews Molecular Cell Biology》(1区,IF:113.915)上发表的综述文章:Roles of mRNA poly(A) tails in r...
Cytoplasmic mRNA decapping is catalyzed by Dcp2 in conjunction with its coactiva... TM Franks,J Lykke-Andersen - 《Molecular Cell》 被引量: 591发表: 2008年 Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae Processing bodies (...
Will CL, Lührmann R. Spliceosome structure and function. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7):a003707. doi: 10.1101/cshperspect.a003707. PMID: 21441581; PMCID: PMC3119917. Huang Y, Gattoni R, Stévenin J, Steitz JA. SR splicing factors serve as adapter proteins for TAP-dep...
An mRNA molecule consists of a single-stranded ribonucleic acid that carries coding information for the translation and processing of functional proteins [141,164]. Early studies on mRNA showed that the molecules can also play multifunctional roles in regulating gene function [245]. Due to its pote...
Structural analysis indicates that the function of the xbp-1 ncRNA depends on a single RNA stem; and this stem forms only in the cleaved xbp-1 ncRNA fragment. Disruption of this stem abolishes the non-coding but not coding function of the endogenous xbp-1 transcript. Thus, cleavage of the...
然而,关于mRNA前体即pre-mRNA的修饰及其功能的优秀综述文章则鲜有报道。近日,mRNA修饰领域的大咖Wendy V. Gilbert教授和她的同事将她们对pre-mRNA中存在的修饰及其对剪接(splicing)影响的最新见解Pre-mRNA modifications and their role in nuclear processing【4】发表在最新一期Quantitative Biology期刊中。
In this case, the second protein may directly influence the function of the target. Exon skipping A specific mechanism of mRNA splicing used to ‘skip over’ an exon normally included in the processed mRNA. Thus, in this case, the final processed mRNA will not include this exon. Nuclear ...