RNA Structure Has a Biological Role RNA structure is thought to play a central role in many cellular processes, including transcription initiation, elongation and termination, mRNA splicing, and retroviral infection of eukaryotic cells. Perhaps the most striking exam...
Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex Cryo-electron microscopy structures ofDrosophilaDicer-2–R2D2 complexes with and without small interfering RNA reveal how the RNA is presented to Argonaute in the correct orientation for viral gene silencing. ...
12,13]. An important impact of RNA editing is its ability to challenge the central dogma of biology. When RNA editing takes place in the coding sequence (CDS) region of an mRNA, where an I is recognized as a G or
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J. 23, 4727–4737 (2004). Article CAS PubMed PubMed Central MATH Google Scholar Xiao, Y., Maeda, S., Otomo, T. & MacRae, I. J. Structural basis for RNA slicing by a plant ...
(total 154), differing in codon usage were tested inE. coli,and around 250-fold expression level differences were recorded among these 154 variants. Further, substitutions in the first 40 nucleotides around thestart codonwere found to strongly affect mRNA secondary structure and ultimately affect ...
同时,环形RNA主要位于细胞质中不受RNA外切酶的影响,更加稳定不易降解。4月25日最新一期Cell杂志在线发表了中科院生化与细胞所陈玲玲研究组合作完成的题为“Structure and degradation of circular RNAs regulate PKR activation in innate immunity”的研究论文首次揭示环形RNA降解和结构调控天然免疫应答。
Our work, for the first time, gave a decided answer to the long-standing question that whether RNA G-quadruplex structures exist in living eukaryotic cells. Given the presence of a large number of RNA G-quadruplex structure in plants, the next step is to unravel their individual regulatory ...
RNA structure probing uncovers RNA structure-dependent biological functions Main Understanding the genetic and transcriptomic determinants of cell identity remains a key question in biology. Toward this goal, numerous groups have developed technologies to interrogate different aspects of the genome and transcr...
RNA structure is intimately connected to each step of gene expression. Recent advances have enabled transcriptome-wide maps of RNA secondary structure, called ‘RNA structuromes’. However, previous whole-cell analyses lacked the resolution to unravel th
A better understanding of the sequence dependence of thermodynamics for RNA structures will improve the accuracy of the RNA secondary structure prediction programs such as MFOLD and RNA structure. He earned his Ph.D. in 2005. ...