As a Bayesian deep generative model, veloVI can output a posterior distribution over velocities at the cell-gene level. This distribution can be used to quantify an intrinsic uncertainty over the first-order directions that a cell can take in the gene space. In downstream analyses, velocity is...
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465, 1033–1038 (2010). Article CAS PubMed PubMed Central Google Scholar Wang, Y. et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal...
针对DRS开发的软件也层出不穷,例如用于三代定量的Bambu (Nat Methods,2023)和NanoCount (Nucleic Acids Research,2022),用于融合基因鉴定Fusionseeker (Cancer Res,2023),以及用于转录本识别的Isoquant (Nat Biology,2023)和LAFITE(Advanced Science,2022)。随着新一代试剂盒RNA004的诞生,DRS在产量、质量以及修饰检测...
2024年4月16日,Cell Stem Cell在线发表了清华大学沈晓骅团队题为“Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence”的研究论文。 该研究报道了RNA exosome通过影响核糖体RNA、信使RNA和非编码RNA的...
This review summarizes common algorithms and tools in RNA computational biology, with a focus on applications of expert system, machine learning, and deep learning to ncRNA identification, ncRNA target prediction, RNA modification, RNA secondary structure detection, RNA-protein interaction and RNA ...
2014;15(12):1–21 Available from: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0550-8. Cited 4 Nov 2022. Soneson C, Love MI, Robinson MD. Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences. F1000Research. 2015;4:1521 /pmc/...
1、Insertion of an Alu element in a lncRNA leads to primate-specific modulation of alternative splicing.Nature Structural and Molecular Biology,2016. 模型:可变剪切 细胞类型:human (HeLa,293T)、mouse (N2a,3T3) 定位:细胞核(FISH) 浓度:N/A ...
The current Chinese RNA research is mainly focused on computational RNomics, RNA biology and medicine, and RNA technology and genetic resources, achieving a relatively complete picture with respect to RNA scientific research and innovation.从1869年瑞士化学家米歇尔发现核酸, 至今已有150年. 核酸包含脱氧...
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a
Replicative DNA polymerases cannot initiate DNA synthesis de novo and rely on dedicated RNA polymerases, primases, to generate a short primer. This primer is then extended by the DNA polymerase. In diverse archaeal species, the primase has long been know