To assess the significance of predicted structures, e.g. to estimate the false discovery rate in a genomic screen for ncRNAs, one should therefore compare the genomic predictions to the results obtained on randomized data with the same dinucleotide content. In the case of single sequences, there...
One of the essential processing events during pre-mRNA maturation is the post-transcriptional addition of a polyadenine [poly(A)] tail. The 3'-end poly(A) track protects mRNA from unregulated degradation, and indicates the integrity of mRNA through recog
One of the essential processing events during pre-mRNA maturation is the post-transcriptional addition of a polyadenine [poly(A)] tail. The 3'-end poly(A) track protects mRNA from unregulated degradation, and indicates the integrity of mRNA through recog
Introduction MicroRNAs (miRNAs), an abundant family of noncoding endogenous RNAs, commonly exist in plants, animals and microbes, and regulate gene expression at the post-transcriptional level by complementary base pairing and/or at the transcriptional level by DNA methylation [1–3]. It has been...