Stephen Buratowski, in Current Opinion in Cell Biology, 2000 RNA polymerase can be envisaged as a roughly ‘crab claw’ or ‘clam’ shaped molecule, with the bottom half consisting mainly of the largest subunit β′ and the upper half containing most of the second largest subunit β. Several...
Figure 7.1.Schematic ncRNA roles and functions around a protein-codinglocus. Depicted in this scheme is the central paradigm of biology, the transcription of a protein-coding gene, the splicing of the primary transcript, and its subsequent translation into proteins. Complementary depicted is the tran...
indicating that we can study the impact of RNase treatment at the complex level and not just the protein level. We calculated the significance for the different complexes by multiplying the independent shiftp-values of each partner using Fisher’...
【1】In considering an overview of microRNA biology, it is useful to consider microRNAs as a part ofcellular communication. 在考虑 microRNA 生物学的概述时,将 microRNA 视为细胞通讯的一部分是很有用的。 At the simplest level, microRNAs a...
lincRNA-derived small open reading frames are rapidly being described and can give rise to functional micropeptides, suggesting the need to revise the definition of some lincRNA loci to coding loci and the potential for loci to possess both coding and non-coding functions. Abstract Long intergeni...
a structure mutant (MT) version of these RNAs, with a few disrupted paired bases, into another population of cells (Fig.2fandMethods). After performing sc-SPORT, we first confirmed that we can observe structural differences between the wildtype (WT) and MT RNAs at the level of pseudobulk ...
“ir” refers to a model in which both splice sites can be used or not used, similar to the “intron retention” event in classical definition. We used the SUVA pipeline to detect AS events from short read RNA-seq data based on the five different splicing patterns described above. In ...
Posts about RNA Biology, Cancer and Therapeutics written by sjwilliamspa, Dr. Pati, 2012pharmaceutical, Irina Robu, and Dr. Sudipta Saha
Urinary CASC2 level did not correlate with any parameters of lupus activity (Supplementary Table S1). Figure 3. Comparison of urinary lncRNA levels between patients with different classes of lupus nephritis: (A) metastasis-associated lung carcinoma transcript 1 (MALAT1); (B) cancer susceptibility ...
Pseudoknots are even contributing, sometimes to the extent of definition, to the alternation of the gene expression of many viruses [25,26,27]. 2.2. Syntactic Pattern Recognition The underlying model of the proposed predicting methodology of pseudoknots in RNA structures is that of syntactic pattern...