Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus particle. The structure of viral RNA is believed ...
Influenzavirus AHeadNeuraminidaseThe influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the NA head with a stalk has never been determined. The NA head from an N9 subtype influenza A virus, A/tern/Australia/G70C/1975 (H1N9)...
Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J 2008;22:3638-3647.Andy Ka-Leung Ng,Hongmin Zhang,Zongli Li,Jin-huan Liu,Paul Kay-Sheung Chan,Pang-Chui Shaw, et al.Structure of the influenza virus A H5N1 ...
Electron microscopy of influenza virus. Credit: CDC A team of researchers from the U.K., Australia and the U.S. has mapped the structure of the influenza A virus genome. In their paper published in the journalNature Microbiology, the group describes their genetic analysis of the virus and w...
There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been sol...
T. (1970). The structure of influenza virus. I. The polypeptides of the virion. Virology 42, 890-904.Schulze, I. T. 1970. The structure of influenza virus. I. The polypeptides of the virion. Virology 42:890-904.SCHULZE, I. T. (1970). The structure of influenza virus. I. The ...
We have constructed an operational antigenic map of the hemagglutinin of influenza virus A/PR/8/34, which indicates the presence of five immunodominant antigenic regions exhibiting various degrees of operational linkage. These sites have been located by the identification of changed amino acid residues...
Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis p pBackground/p pInfluenza A virus infects not only humans, but also other species including avian and swine. If a novel influenza A subtype acquires the a... Y Furuse,A Suzuki,T ...
Influenza A virus was chosen as the pathogen of interest as (i) it is an important, globally-circulating human pathogen, (ii) influenza is well characterized antigenically, (iii) a precise and repeatable serological assay was available, and (iv) the human population receives almost no influenza...
Influenza B virus is one of two types of influenza virus that cause substantial morbidity and mortality in humans, the other being influenza A virus. The inability to provide lasting protection to humans against influenza B virus infection is due, in part, to antigenic drift of the viral surfac...