N9 neuraminidase structureThe influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the NA head with a stalk has never been determined. The NA head from an N9 subtype influenza A virus, A/tern/Australia/G70C/1975 (H1N9), was...
There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been sol...
We previously determined the three-dimensional structure of the complex between staphylococcal enterotoxin C3 (SEC3) and the extracellular portion of the β chain (mouse Vβ8.2Jβ2.1Cβ1) of a mouse TCR (designated 14.3.d) specific for a hemagglutinin peptide of influenza virus bound to I-Ed...
The severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human-infecting bunyavirus, which utilizes two envelope glycoproteins, Gn and Gc, to enter host cells. However, the structure and organization of these glycoproteins on virion
A customized version of RosettaDock’s high-resolution stage is then used to generate an ensemble of models focused around the epitope for discrimination. Full size image Sample binding analyses: Fab NC41–influenza virus neuraminidase N9 and Fab 44.1–hen egg-white lysozyme complexes The main ...
Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex J. Mol. Biol (1992) B.W. Matthews Solvent content of protein crystals J. Mol. Biol (1968) A. Krebber et al. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires ...
The severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human-infecting bunyavirus, which utilizes two envelope glycoproteins, Gn and Gc, to enter host cells. However, the structure and organization of these glycoproteins on virion surface are not yet known. Here we describe...
The structure of the NA head with a stalk has never been determined. The NA head from an N9 subtype influenza A virus, A/tern/Australia/G70C/1975 (H1N9), was expressed with an artificial stalk derived from the tetrabrachion (TB) tetramerization domain from Staphylothermus marinus. The NA...
J. et al. Crystal structure of the human class II MHC protein HLA- DR1 complexed with an influenza virus peptide. Nature 368, 215–221 (1994). 18. Stewart-Jones, G. B., McMichael, A. J., Bell, J. I., Stuart, D. I. & Jones, E. Y. A structural basis for immunodominant ...
The crystal structure of the complex between neuraminidase from influenza virus (subtype N9 and isolated from an avian source) and the antigen-binding fragment (Fab) of monoclonal antibody NC41 has been refined by both least-squares and simulated annealing methods to an R-factor of 0.191 using ...