Virus adsorption has been known for some time to be a property of the haemagglutinin glycoprotein (HA) of the virus membrane and the recent direct implication of HA in membrane fusion (1) confirms previous conclusions from a variety of observations that HA is also involved in this activity (2...
禽流感病毒血凝素糖蛋白(ha)的结构及其生物学功能 the structure and biology function of avian influenza virus hemagglutinin glycoprotein208阅读 文档大小:799.72K 3页 558416上传于2015-05-24 格式:PDF 禽流感病毒血凝素糖蛋白(ha)的结构及其生物学功能 热度: 一种编码重组禽流感病毒HA蛋白的基因、病毒样颗粒...
Influenza A Virus is a virus belonging to the Orthomyxoviridae family with a negative-sense RNA genome consisting of eight segments. It has an enveloped structure, neuraminidase [N], and hemagglutinin activity [H] proteins, and measures 80–120 nm in diameter. ...
The pandemic influenza virus (2009 H1N1) was recently introduced into the human population. The hemagglutinin (HA) gene of 2009 H1N1 is derived from "class... I Manabu,I Kimihito,Y Reiko,... - 《Plos One》 被引量: 272发表: 2010年 Novel Inhibitors of Influenza Virus Fusion: Structure-Ac...
Although we are beginning to understand the processes that underlie the evolutionary dynamics of seasonal influenza viruses, the timing and nature of emergence of new virus strains remain mostly unpredictable. In this Review, we discuss recent advances in understanding the molecular determinants of ...
The adaptive immune response to influenza virus infection is multifaceted and complex, involving antibody and cellular responses at both systemic and mucosal levels. Immune responses to natural infection with influenza virus in humans are relatively broad and long-lived, but influenza viruses can escape...
Proteolytic activation of the influenza virus hemagglutinin: The structure of the cleavage site and the enzymes involved in cleavage - ScienceDirect The cleavage site of the hemagglutinin of influenza strains A/chick/Germany/49 (H10), A/Port Chalmers/1/73 (H3), A/Victoria/3/75 (H3), and A...
For example, an influenza A virus isolated from a patient in Puerto Rico in 1934 is given the strain designation A/Puerto Rico/8/34. The envelope glycoproteins are the hemagglutinin (HA) and neuraminidase (NA). HA mediates binding of the virus to sialic (also known as neuraminic) acid ...
Bizebard, T. et al. Structure of influenza virus haemagglutinin complexed with a neutralizing antibody.Nature376, 92–94 (1995). CASPubMedGoogle Scholar Margine, I. et al. H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice.J. Virol.87, 4728...
Influenza A viruses are surface glycoprotein,single stranded,segmented RNA viruses that are found in birds. Influenza A subtypes are based on the virus glycoproteins hemagglutininn(HA) and neuraminidase (NA). There are 16 different HA antigens and