influenza virusessedimentationsialidasevirologyThis paper describes methods for the disruption of particles of influenza B virus (LEE strain), efficiently and without cleavage of covalent bonds, into subunits very much smaller than the original virus. Disruption with sodium dodecyl sulphate abolishes hem...
Studies of the antigenicity of the HA of influenza B virus have been hampered by lack of knowledge of its structure. To address this gap, two possible models have been inferred for this structure, based on two known structures of the homologous HA of the influenza A virus (subtypes H3 and...
There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been sol...
The crystal structure of the hemagglutinin (HA) of influenza virus A/Aichi/68 (H3N2) from the X-31 reassortant virus was reported in 1981, but as yet there are no X-ray diffraction structures for hemagglutinins of other types or even subtypes of influenza virus. We have used site-directed...
Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus partic
The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid. Influenza virus neuraminidase catalyses the cleavage of terminal sialic acid, the viral receptor, from carbohydrate chains on glycoproteins and glycolipids... W P,Burmeister,R W,... - 《Embo ...
A Defective Interference-Like Phenomenon of Human Hepatitis B Virus in Chronic Carriers Defective interfering (DI) particles have been found in many RNA and DNA viruses of bacteria, plants, and animals since their first discovery in influenza ... D Chen - 《Journal of Virology》 被引量: 190发...
The best studied example of a simple helical virus is tobacco mosaic virus (TMV). The TMV virion is a rigid rod 18nm in diameter and 300nm long (Fig. 2.2B). It contains 2130 copies of a single capsid protein of 17.5kDa. In the right-hand helix, each protein subunit has six nearest...
Structure of influenza virus panhandle RNA studied by NMR spectroscopy and molecular modeling. The structure of a 34 nucleotide RNA molecule in solution, which contains the conserved panhandle sequences, was determined by NMR spectroscopy and molecul... Cheong Hae-Kap,C Chaejoon,Lee Yeon-Sook,.....
No activity was observed for A/H1N1, A/H5N1, A/H7N2, and B viruses. The activity of 4c was reduced considerably when added 30 min or later postinfection, indicating that 4c inhibits an early step in virus replication. 4c and its congeners inhibited influenza A/H3N2 virus-induced ...