describe an X-ray crystal structure of Mxra8, an entry receptor for arthritogenic alphaviruses, and cryo-EM structures of Mxra8 bound to CHIKV. Mxra8 has an unusual Ig-like domain architecture with a head-to-head arrangement, with domain 1 emanating from a loop of domain 2. Mxra8 ...
The 3 Dimensional structure of a protein is an expedient for structure based drug design and identifying the conformational epitopes that are foremost for designing the vaccines. Chikungunya (CHIKV) is a heat sensitive RNA virus which causes a viral disease which is transmitted in humans by human-...
The crystal structure of chikungunya (CHIKV) virus capsid protease domain has been determined at 2.2 Å. Structure reveals a chymotrypsin-like protease fold with a conserved hydrophobic pocket in CHIKV capsid protein (CP) for interaction with the cytoplasmic tail of E2 (cdE2) similar to the ...
et al. Cryo-EM structure of chikungunya virus in complex with the Mxra8 receptor. Cell 177, 1725–1737 (2019). Article CAS Google Scholar Song, H. et al. Molecular basis of arthritogenic alphavirus receptor MXRA8 binding to chikungunya virus envelope protein. Cell 177, 1714–1724 (2019...
In this regard, an interesting report using chikungunya virus (CHIKV) described the process of viral 3′-UTR evolution in different hosts (68). In this case, duplication of direct repeats (DRs) in the CHIKV 3′ UTR was found to be beneficial for viral replication in mosquito cells rather...
Poliovirus Chapter © 2016 Function of Chikungunya Virus Structural Proteins Chapter © 2016 Etiology of Influenza Chapter © 2016 References Argos P, Kamer G, Nicklin MJH, Wimmer E (1984) Homology between proteins of the animal picornaviruses and a plant comovirus. Identification of a cons...
et al. Cryo-EM structure of chikungunya virus in complex with the Mxra8 receptor. Cell 177, 1725–1737 (2019). CAS PubMed PubMed Central Google Scholar Mangala Prasad, V., Klose, T. & Rossmann, M. G. Assembly, maturation and three-dimensional helical structure of the teratogenic ...
Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3′UTR Variation in Chikungunya Virus RNA secondary structure in the viral genome plays an important role in the lifecycle of alphaviruses; however the specific role of RNA structure in ... EA Madden,KS Plante,CR Morrison,... - ...
et al. Structures of Ebola and Reston virus VP35 oligomerization domains and comparative biophysical characterization in all ebolavirus species. Structure 27, 39–54 (2019). Article CAS PubMed Google Scholar Henss, L. et al. Suramin is a potent inhibitor of Chikungunya and Ebola virus cell ...
For the glycoprotein E1, E2, and E3, crystal structures of the SINV E2-E1 heterodimer at low pH (PDB code 3MUU) and immature envelop glycoprotein complex of Chikungunya virus (PDB code 3N40) were fitted into the 3.5 Å cryo-EM map using UCSF Chimera41. The amino acid sequences we...