Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental...
Department of Virology, College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana Joseph Humphrey Kofi Bonney, Deborah Pratt, Magdalene Ofori, Abigail Abankwa, Yaw Awuku-Larbi, Musah Salisu, Ama Amankwa Ofosua Mante, Stella Bour, Miriam...
Journal of Medical Virology, 92(8), 941–955. Article CAS PubMed Google Scholar Yung, C.-F., et al. (2015). Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore. The American Journal of Tropical Medicine and ...
Alphavirus nsP1 synthesizes the 5′ end Cap-0 structure of viral RNAs. However, the molecular basis of the capping process remains unclear. We determine high-resolution cryoelectron microscopy (cryo-EM) structures of Chikungunya virus nsP1 in complex with m7GTP/SAH, covalently attached m7GMP, ...
TG Phan,TA Nguyen,H Yan,... - 《Archives of Virology》 被引量: 87发表: 2005年 Molecular epidemiology of HIV, HBV, HCV, and HTLV-1/2 in drug abuser inmates in central Javan prisons, Indonesia. This study was conducted to determine the current molecular prevalence of human immunodeficiency...
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry of the virus into the CNS, severe neurological life-threatening conditions may manifest that are associated with high morbidity and mortality. The currently...
Ebolavirus - Validated by L. Avena and Dr. A. Griffiths, Department of Virology and Immunology, Texas Biomedical Research Institute. Phommanivong, V, et al. ”Co-circulation of the dengue with chikungunya virus during the 2013 outbreak in the southern part of Lao PDR” Tropical Medicine and ...
University of Chinese Academy of Sciences, Beijing, China Ziwei Zhou, Qingxing Wang, Yi Jiang, Hualiang Jiang, Leike Zhang, Xuekui Yu & H. Eric Xu State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, Chi...
Serial passages of chikungunya virus in the presence of nucleoside analogs favored the appearance of substitution G641D in the RNA helicase nsP2 [40]. This variant increased replication fidelity through mechanisms linked to reduced helicase activity, increased replication kinetics, and resistance to low...
RNA virus genomes can consist of double-stranded RNA (dsRNA) or single-stranded (ssRNA) (Fig.1a). In turn, the ssRNA viruses can be classified into positive sense (+RNA) and negative sense (−RNA) viruses (Fig.1a), depending on the translatability of their genetic material. As summarise...