Chikungunya virus infectionRe-emerging diseasesPublic healthHost immunityAlong with the running COVID-19 pandemic by the severe acute respiratory syndrome coronavirus 2, the chikungunya virus is already known as the causative agent of re-emerging chikungunya fever in many countries after several years of...
New insights into chikungunya virus infection and pathogenesis. Annu. Rev. Virol. 8, 327–347 (2021). Article PubMed Google Scholar Longbottom, J. et al. Aedes albopictus invasion across Africa: the time is now for cross-country collaboration and control. Lancet Glob. Health https://doi....
Co-infection withand chikungunya virus (CHIKV) has been reported in humans, but theimpact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure tosuppresses CHIKV-associated pathologies in mice. Mechanistically,infection induces IFN纬, which reduces viraemia of a ...
Chikungunya virusinfection can be transmitted from mother to child, mainly during delivery. Although the virus is not teratogenic during pregnancy, as theplacentaseems to act as a barrier to transmission, acuteintrapartumviremia is associated with vertical transmission in almost 50% of cases and has ...
Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in hum
8 Attempts to isolate the pathologic agent from symptomatic individuals during the outbreak also diverged from previous experience with dengue virus (DENV): Inoculation of infant mice with serum samples from symptomatic individuals resulted in death of the animals. In contrast, DENV infection is ...
measured by the presence of IgM and IgG antibodies, among individuals with suspected acute chikungunya infection, with suspected other arbovirus infection, with undifferentiated acute febrile illness or who were healthy. Studies reporting anti-DENV IgM and/or IgG during outbreak and non-outbreak setting...
Previous studies in animal models indicate that humoral immunity can protect against CHIKV infection, but despite the potential efficacy of B-cell-driven intervention strategies, there are no virus-specific vaccines or therapies currently available. In addition, CHIKV has been reported to elicit long...
Chikungunya virus (CHIKV) is a re-emerging arbovirus known to cause chronic myalgia and arthralgia and is now considered endemic in countries across Asia and Africa. The tissue tropism of CHIKV infection in humans remains, however, ill-defined. Due to th
This concern was further solidified by the recent incursion of the virus into the Western hemisphere, a region without pre-existing immunity. Nonhuman primates (NHPs) serve as excellent animal models for understanding CHIKV pathogenesis and pre-clinical assessment of vaccines and therapeutics. NHPs ...