Now, we have enzyme-linked immunosorbent assays and polymerase chain reactions to detect this virus in blood. These modalities are quicker and more sensitive and specific. In recent times, physicians have started using nonsteroidal antiinflammatory drugs and disease-modifying antirheumatic drugs to ...
vertebrate hosts. With most arboviruses, human involvement in this transmission cycle is incidental [1]. In terms of public health significance, the mosquito is the most important vector of arbovirus transmission. It is estimated that
Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in hum
Nanobodies (Nbs) are single-domain antibody fragments derived from camelid heavy chain antibodies. Nbs are the smallest naturally occurring intact antigen-binding fragments (15 kDa) derived only from the variable region of the heavy chain; they lack the fragment crystallisable (Fc) region and have...
However, the real impact of the CHIKV sylvatic cycle in humans and mechanisms underlying its emergence still remains unknown. One thousand four hundred nine suspect cases of CHIKV infection, recruited from 5 health facilities located in Kedougou region, south-eastern Senegal, between May 2009 to ...
Genomic sequencing has revealed that the first case of chikungunya fever (CHIKF) reported in Brazil was an infection by the Asian lineage introduced in a northern state in 2014, while another case reported seven days later in a north-eastern state represented the first known introduction of the...
Keywords:Chikunguniya; Real time polymerase chain reaction; Aedes aegypti; Aedes albopictus Abbrevations:CHIK V: Chikungunya Virus; CMRL: Central Molecular Research Laboratory; SGRRIM & HS: Shri Guru Ram Rai Institute of Medical & Health Science; CDNA: Compleme...
Chikungunya infection, while typically not fatal, can lead to chronic symptoms such as persistent joint pain that may last for months to years, as observed in 43–72% of La Réunion’s population infected with CHIKV, with symptoms persisting up to two years6,7,8. These prolonged symptoms, ...
The term “chikungunya” is derived from the word kungunyala, from the African kimakonde language, which means “one who slouches” in reference to the stooped posture adopted by the people because of the unbearable joint and muscular pain1. It is an arboviral infection caused by the chikungun...
Humoral immunity has been identified as a potential immune correlate of protection against CHIKV infection. Many CHIKV vaccine candidates are being developed currently, with the goal of generating long-term humoral responses. Clinical trials on these various vaccine candidates demonstrate the role of ...