Leslie W.University of CalgaryVogelUniversity of CalgaryHans J.University of CalgaryCurrent Topics in Medicinal ChemistryClarke, T. E., L. W. Tari, and H. J. Vogel. Structural biology of bacterial iron uptake systems. Curr. Top. Med. Chem. 1:7-30. 2001....
Combining alloy design with additive manufacturing process design creates α–β titanium–oxygen–iron alloys that are both strong and ductile, with the potential to revitalize off-grade sponge titanium and thereby reduce the carbon footprint of the titanium industry. Tingting Song , Zibin Chen & ...
Vogel Structural biology of bacterial iron uptake Biochim. Biophys. Acta, 1778 (2008), pp. 1781-1804 View in ScopusGoogle Scholar [57] K.D. Krewulak, H.J. Vogel TonB or not TonB: is that the question? Biochem. Cell Biol., 89 (2011), pp. 87-97 View in ScopusGoogle Scholar [58...
The structural mechanism for iron uptake and release by transferrins. Biosci. Biotechnol. Biochem. 64, 1328-1336.Hirose, M. The Structural Mechanism for Iron Uptake and Release by Transferrins. Biosci., Biotechnol., Biochem. 2000, 64 (7), 1328-1336....
Mycobacterium tuberculosis; salicylate synthase; siderophore; iron; co-crystal structure; anti-virulence therapy; tuberculosis1. Introduction Iron is a fundamental cofactor in most bacterial species, including mycobacteria [1,2,3]. In mammals, it is mainly bound in its oxidized form (Fe3+) to ...
Shorter exposure times may stimulate growth by promoting the mass transfer and nutrient uptake of the microbial cells after the treatment loosens the cell walls of the sample [57]. In contrast, prolonged exposure, according to Ref. [58], could result in cell damage and reduced viability due ...
Structural biology articles within Nature CommunicationsFeaturedArticle 02 July 2015 | Open Access Crystallographic structure of a small molecule SIRT1 activator-enzyme complex Sirtuins are NAD+-dependent deacylases implicated in the regulation of stress responses, bioenergetics and epigenetic control. ...
Escherichia coli Fur is a global transcriptional regulator that controls the expression of more than 90 genes mainly implicated in iron uptake but also in other fundamental processes, such as the regulation of oxidative stress, acid tolerance, and bacterial virulence determinants (1). E. coli Fur ...
The appearance of the electron density and the refinement of the B factors were used as guides to include or exclude ion sites. The protein structure around the sites is quite good. The presence of iron in the selenomethionine protein sample may indicate the adventitious uptake of iron during ...
Since nucleic acids (DNA and RNA) play very important roles in cells, they are molecular targets of many clinically used drugs, such as anticancer drugs and antibiotics. Because of clinical demands for treating various deadly cancers and drug-resistant strains of pathogens, there are urgent needs...