Last, we address how the iron acquisition strategiesof pathogenic bacteria may be exploited for the developmentof novel prophylactics or antimicrobials.doi:10.1128/9781555819286.ch3Jessica R. SheldonHolly A. LaaksoDavid E. HeinrichsSheldon JR, Laakso HA, Heinrichs DE. Iron acquisition strategies of ...
To overcome the low solubility and bio-availability of iron, bacteria have evolved multiple systems to acquire iron from various sources such as heme, hemoglobin and ferritin. The molecular basis of iron acquisition from heme and hemoglobin have been extensively studied; however, very little is ...
Iron is principally stored in ferritin, a large molecule able to bind several thousand iron ions. Although host ferritins represent a mine of iron for pathogens, studies of the mechanisms involved in its acquisition by bacteria are scarce. In the human opportunistic pathogen Bacillus cereus, the ...
Despite its abundance, Fe is mostly present as a ferric form in soils, strongly limiting its bioavailability. To overcome the challenge of Fe acquisition, many microorganisms produce sidero- phores to retrieve Fe from natural sources. Another ubiquitous feature of bacteria in natural environments is ...
Apostol,M,Baret,P,Serratrice,G,Desbrières,J,Putaux,JL,Stebé,MJ,Expert,D,Pierre,JL.Self-assembly of an amphiphilic iron(III) chelator: mimicking iron acquisition in marine bacteria.Angewandte Chemie International Edition. 2005Apostol, M., Baret, P., Serratrice, G., Desbrieres, J., ...
These results provide the first evidence that ExbB-ExbD is involved in inorganic iron uptake and is an essential part of the iron acquisition pathway in cyanobacteria. The involvement of an ExbB-ExbD system for inorganic iron uptake may allow cyanobacteria to more tightly maintain iron homeostasis,...
Pathology Iron acquisition by uropathogenic Escherichia coli| ChuA and Hma heme receptors as virulence determinants and vaccine targets UNIVERSITY OF MICHIGAN Harry L.T. Mobley HaganErin CourtneyIn Gram negative bacteria, specific outer membrane receptors facilitate the import of iron-chelating siderophores...
Characterization of a novel iron acquisition activity that coordinates the iron response with population density during iron replete conditions in Bacillus subtilis J Bacteriol, 199 (2017), pp. 1-23 Google Scholar 37 C. Carpenter, S.M. Payne Regulation of iron transport systems in Enterobacteriaceae...
When intracellular levels of iron are low, bacteria turn on multiple iron uptake systems for iron acquisition. In B. subtilis, those iron acquisition systems are composed of transporters for the import of elemental iron, ferric citrate, ferrioxamine, ferrichrome, and petrobactin9. A key ...
The active or passive acquisition of antibodies to exotoxins usually eliminates toxemia but not infection. Direct destruction of bacteria by specific antibodies and complement occurs only in a few bacterial species. Many pathogens do not produce exotoxins but nevertheless are able to invade tissues of...