International Journal of Medical MicrobiologyBraun, V. (2001) Iron uptake mechanisms and their regulation in pathogenic bacteria. Int. J. Med. Microbiol. 291: 67-79.Braun V: Iron uptake mechanisms and their regulation in pathogenic bacteria. Int J Med Microbiol 2001, 291 (2) : 67-79. Pub...
Iron acquisition systems are important virulence factors in pathogenic bacteria. To identify these systems in Acinetobacter baumannii, the transcriptomic response of the completely sequenced strain ATCC 17978 under iron limiting conditions was investigat
While our understanding of molecular mechanisms involved in iron uptake from the soil is relatively well developed, information regarding the mechanisms that serve to move iron into subcellular compartments, like mitochondria, chloroplasts and vacuoles, is just beginning to emerge. This re...
In this study, we showed that the differentiation of regulatory T cells in the intestinal mucosa was critically dependent on their higher levels of intracellular iron, the uptake of which was promoted by pentanoate, a microbiota-produced short-chain fatty acid (SCFA). Decreased cellular iron leve...
fumigatus probably employs vacuolar iron storage, as indicated by the iron-inducible expression of CccA [18], the ortholog of the vacuolar iron importer Ccc1p of S. cerevisiae [1•]. In contrast to bacteria, plants and animals, however, fungi lack ferritin-mediated iron storage and ...
Regulatory mechanisms of ferroptosis. The left panel illustrates the activation pathway of ferroptosis. The middle panel depicts the core process of ferroptosis mediated by iron ions, and the right panel shows the inhibitory pathway of ferroptosis. NOXs: NADPH oxidases; CTH: cystathionine gamma-lyase...
Restricted iron availability is a major obstacle to growth and survival of pathogenic bacteria during infection. In contrast to Gram-negative pathogens, little is known about how Gram-positive pathogens obtain this essential metal. We have identified two Streptococcus pneumoniae genetic loci, pit1 and...
In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus ...
Ratledge C, Dover LG: Iron metabolism in pathogenic bacteria. Annu Rev Microbiol. 2000, 54: 881-941. 10.1146/annurev.micro.54.1.881. Article CAS PubMed Google Scholar Braun V: Iron uptake mechanisms and their regulation in pathogenic bacteria. Int J Med Microbiol. 2001, 291: 67-79. 10...
The antifungal activity of copper has been well-documented for many centuries. Indeed, copper salts have been traditionally used in many countries to control different plant pathogenic fungi. However, using copper-based nanoparticles rather than copper salts has recently gained significant interest, as ...