We found that T follicular helper (T-FH) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses.doi:10.1038/s41590-023-01520-2Linterman, Michelle A....
A8.34CD1C + dendritic cells are overrepresented in lymph nodes of early arthritis patients and related to B cell responses We hypothesize that an in-depth analysis of DCs within LNs of at risk individuals and early arthritis patients can provide a better understanding of immune function and dysreg...
Stromal cellsare tissue-resident mesenchymal cells that provide the structure (Ancient Greek στρῶμα, strôma, ‘bed’) andextracellular matrix(ECM) of organs and support the function of the organ by aiding organ-specific functional cells. Apart from their role in building tissue, recent...
Rimando1, Hao-Hsiang Wu2,Yu-An Liu3, Chien-Wei Lee4, Shu-Wen Kuo3, Yin-Ping Lo4, Kuo-Fung Tseng5,Yi-Shiuan Liu3 & Oscar Kuang-Sheng Lee3,6,7 Lineage commitment and differentiation of mesenchymal stromal cells (MSCs) into osteoblasts in vitro is enhanced...
One important aspect of mesenchymal stromal cells (MSCs)-mediated immunomodulation is the recruitment and induction of regulatory T (Treg) cells. However, we do not yet know whether MSCs have similar effects on the other subsets of Treg cells. Herein, we
Pharmacological inhibition of αV-integrin reduced the profibrotic action of cardiac PW1CD51cells and was associated with improved cardiac function and animal survival following MI coupled with a reduced infarct size and fibrotic lesion. These data identify a targetable pathway that regulates cardiac ...
Marrow stromal cells administrated intracisternally to rats after traumatic brain injury migrate into the brain and improve neurological function 来自 知网 喜欢 0 阅读量: 58 作者:胡德志,周良辅,朱剑虹 摘要: Marrowstromalcells (MSCs)havebeenreportedtotransplantintoinjuredbrainviaintravenousorintraarterialor...
Human microvascular endothelial cells (HMVECs) were treated with thrombin to disrupt the EC integrity followed by incubation with CTCE or SDF-1α. Barrier function was determined by trans-endothelial electrical resistance assay. CTCE-induced alterations in miRNA expression and signaling pathways involved...
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, actively contribute to the formation of the tumour microenvironment, wherein they are converted into tumour-associated MSCs (TA-MSCs). TA-MSCs regulate tumour growth, metastasis and responses to chemotherapy and radiotherapy by ...
systemically administered enucleated cells expressing two types of chemokine receptor and an endothelial adhesion molecule enhanced the delivery of an anti-inflammatory cytokine to diseased tissue (with respect to unmodified stromal cells and to exosomes derived from bone-marrow-derived stromal cells), atte...