We found that T follicular helper (T-FH) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses.doi:10.1038/s41590-023-01520-2Linterman, Michelle A....
A8.34CD1C + dendritic cells are overrepresented in lymph nodes of early arthritis patients and related to B cell responses We hypothesize that an in-depth analysis of DCs within LNs of at risk individuals and early arthritis patients can provide a better understanding of immune function and dysreg...
Stromal cells are tissue-resident mesenchymal cells that provide the structure (Ancient Greek στρῶμα, strôma, ‘bed’) and extracellular matrix (ECM) of organs and support the function of the organ by aiding organ-specific functional cells. Apart from their role in building tissue, re...
we do not yet know whether MSCs have similar effects on the other subsets of Treg cells. Herein, we studied the effects of MSCs on CD8+CD28−Treg cells and found that the MSCs could not only increase the proportion of CD8
Pharmacological inhibition of αV-integrin reduced the profibrotic action of cardiac PW1CD51cells and was associated with improved cardiac function and animal survival following MI coupled with a reduced infarct size and fibrotic lesion. These data identify a targetable pathway that regulates cardiac ...
Rimando1, Hao-Hsiang Wu2,Yu-An Liu3, Chien-Wei Lee4, Shu-Wen Kuo3, Yin-Ping Lo4, Kuo-Fung Tseng5,Yi-Shiuan Liu3 & Oscar Kuang-Sheng Lee3,6,7 Lineage commitment and differentiation of mesenchymal stromal cells (MSCs) into osteoblasts in vitro is enhanced...
Cell therapy with bone marrow-derived stem/progenitor cells is a novel option for improving neovascularization and cardiac function in ischemic heart disea... Heeschen,C. - 《Circulation》 被引量: 3857发表: 2004年 Human Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Gliomas The ...
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, actively contribute to the formation of the tumour microenvironment, wherein they are converted into tumour-associated MSCs (TA-MSCs). TA-MSCs regulate tumour growth, metastasis and responses to chemotherapy and radiotherapy by ...
Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells. Diabetes 2015; 64(2): 587-92.Carlsson PO, Schwarcz E, Korsgren O, Le Blanc K. Preserved b-cell function in type 1 diabetes by mesen- chymal stromal ... P Carlsson,D Espes,L Davies,... - 《Cytotherapy》 ...
systemically administered enucleated cells expressing two types of chemokine receptor and an endothelial adhesion molecule enhanced the delivery of an anti-inflammatory cytokine to diseased tissue (with respect to unmodified stromal cells and to exosomes derived from bone-marrow-derived stromal cells), atte...