mesenchymal stem/stromal cellsimmune systeminflammationcancerToll‐like receptorsexosomesanti‐tumor therapyinterleukin‐6Mesenchymal stem or stromal cells (MSCs) are pluripotent cells implicated in a broad range of physiological events, including organogenesis and maintenance of tissue homeostasis as well as ...
Mesenchymal stem/stromal cells (MSCs) have garnered attention for their potential in cancer therapy due to their ability to home to tumor sites. Engineered MSCs have been developed to deliver therapeutic proteins, microRNAs, prodrugs, chemotherapy drugs, and oncolytic viruses directly to the tumor mi...
Remodeling (re-engineering) of a tumor’s stroma has been shown to improve the efficacy of anti-tumor therapies, without destroying the stroma. Even though it still remains unclear which stromal component/-s and what characteristics hinder the reach of nanoparticles deep into cancer cells, we hyp...
Pancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer progression. Extracellular vesicles (EVs), including exosomes and microvesicles, help facilitate ...
This meeting will highlight cutting-edge science and provide insight into recent developments towards therapeutic stromal cell targeting in cancer and chronic inflammatory diseases.Topics Include: Development and Differentiation of Stromal Cells Stromal-Immune Cell Interaction Stromal Cells in Tissue ...
Link:https://vibconferences.be/event/metabolism-in-cancer-and-stromal-cells-2nd-edition WhenNov 26, 2018 - Nov 27, 2018 WhereLeuven, Belgium Submission DeadlineSep 24, 2018 After a successful first edition of the VIB Conference “Metabolism in cancer and stromal cells” in September 2015, we...
Mutual concessions and compromises between stromal cells and cancer cells: driving tumor development and drug resistance 来自 Semantic Scholar 喜欢 0 阅读量: 53 作者:N Pritish,SC Sarode,J Devashree,T Ishita,P Shankargouda,GS Sarode,JK Pal,SN Kumar ...
as the soon-to-be prostate stroma determines embryonal epithelial cells to commit toward prostatic differentiation. Later in life, the appearance of a reactive stroma is linked to the malignant transformation of epithelial cells and cancer progression. In this Review, we discuss the main mesenchymal ...
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk.
Recent studies in molecular and cellular biology have shown that tumor growth and metastasis are not determined by cancer cells alone but also by a variety of stromal cells. The stroma constitutes a large part of most solid tumors, and cancer-stromal cell interaction contributes functionally to tum...