Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritisdoi:10.3390/CELLS8101257Jean-Marc BrondelloFarida DjouadChristian JorgensenCells
The drivers of sporadic gastrointestinal stromal tumors (GISTs) and inflammatory fibroid polyps (IFPs) are well-documented to include molecular alterations in PDGFRA. While a small number of families with germline PDGFRA mutations in exons 12, 14, and 18 have been reported, this observation ...
These cells are originated from both surrounding tissues and bone marrow. However, autophagy effects regarding these stromal cells are not exactly determined yet. Despite the importance of autophagy in crosstalk between cancer cells and stromal cells, it contributes to vascular compartment to finally ...
39 However, this would not explain the redistribution of phosphorylated NCC toward more distal DCT segments and the increased pNCC levels that are found in Umod−/− mice at baseline. Our results suggesting that uromodulin facilitates NCC phosphorylation in stably transfected HEK cells support a...
As a result, there is a uniquely direct and dominant connection between the external environment (the sun/light) and the stromal Cys-redox machinery. By contrast, internal control is possible over the electron fluxes that enter or leave the Cys-redox machinery...
Which nutrients are most limiting for a given tumor is influenced by vascularization (Farnsworth et al., 2014), metabolic cooperation and competition with surrounding stromal and immune cells (Buck et al., 2017, Gupta et al., 2017), and nutrient-scavenging ability (Recouvreux and Commisso, ...
[62].TGFBIgene mutations have been frequently identified in patients with corneal epithelial–stromalTGFBIdystrophies, a group of heterogeneous conditions that are characterized by the progressive loss of corneal transparency [63] resulting in the corneal abnormalities witnessed in transgenic mice [64,65...
Mesenchymal stem cellsStem cellsClinical trialsStromal cellsMesenchymal stromal cells (MSCs), present in the stromal component of several tissues, include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly attracted considerable attention in the clinical field for their ...
Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of...
Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of...