Stepped wedge cluster randomised trials (SW-CRTs) are being used with increasing frequency in health service evaluation. Conventionally, these studies are designed with equally spaced steps, with an equal number of clusters randomised at each step, and data collected at each and every step. Here ...
In contrast, there is little research available pertaining to the design and analysis of multi-arm stepped-wedge cluster randomized trials, utilized to evaluate the effectiveness of multiple experimental interventions. In this paper, we address this by explaining how the required sample size in these...
[1] 杨祖耀,詹思延. 阶梯设计在随机对照试验中的应用. 中华流行病学杂志, 2010. 31(1): 第92-95页. [2] Li, S., et al., Rational and design of astepped-wedgeclusterrandomized trial evaluating quality improvement initiativefor reducing cardiovascular ...
Unequal cluster sizes in stepped-wedge cluster randomised trials: a systematic reviewstepped-wedge trialsystematic reviewcluster randomised trialTo investigate the extent to which cluster sizes vary in stepped-wedge cluster randomised trials (SW-CRT) and whether any variability is accounted for during ...
If the cluster sizes are all equal, a two-sample t-test may be used to compare cluster-level mean responses between the intervention groups. If there are more than 2 treatment arms, a one-way analysis of variance may be used. Sometimes the communities are matched and randomization is done...
The stepped-wedge (SW) cluster randomized controlled trial, in which clusters cross over in a randomized sequence from control to intervention, is ideal for the implementation and testing of complex health service interventions. In certain cases however, implementation of the intervention may pose logi...
The study utilized a stepped-wedge cluster randomized trial design, where the intervention was introduced in a phased manner across different villages. The results showed that the salt substitute was associated with a modest reduction in blood pressure and a lower incidence of hypertension, ...
A stepped wedge cluster randomised controlled trial has been designed to evaluate the impact of the STAT model in 8 community health and outpatient services. The primary outcome will be waiting time from referral to first appointment. Secondary outcomes will be nature and quantity of service ...
The stepped wedge cluster randomised trial: Rationale, design, analysis, and reporting The stepped wedge cluster randomised trial is a novel research study design that is increasingly being used in the evaluation of service delivery type interventions. The design involves random and sequential crossover...
sizere‐estimationstepped‐wedgeThe ability to accurately estimate the sample size required by a stepped‐wedge (SW) cluster randomized trial (CRT) routinely depends upon the specification of several nuisance parameters. If these parameters are misspecified, the trial could be overpowered, leading to ...