Stepped-wedge cluster randomised controlled trials: a generic framework including parallel and multiple-level designs. Statist Med. 2015;34:181-96.K. Hemming, R. Lilford, A.J. Girling, Stepped-wedge cluster randomised controlled trials: a generic framework including parallel and multiple-level ...
[2] Li, S., et al., Rational and design of astepped-wedgeclusterrandomized trial evaluating quality improvement initiativefor reducing cardiovascular events among patients with acute coronary syndromesin resource-constrained hospitals in China. Am Heart J...
Analysis of a standard crossover design focuses on within-cluster comparisons using a paired t-test. A stepped wedge design [13] is a type of crossover design in which different clusters cross over (switch treatments) at different time points. In addition, the clusters cross over in one ...
In contrast, there is little research available pertaining to the design and analysis of multi-arm stepped-wedge cluster randomized trials, utilized to evaluate the effectiveness of multiple experimental interventions. In this paper, we address this by explaining how the required sample size in these...
We used a stepped wedge cluster randomized trial design (see Fig. 1) in which the intervention was sequentially rolled out to participating primary care practices assigned by region in three steps. Each step provides data for both control and intervention periods, and data analysis proceeds by com...
Each time point at which a new cluster receives the intervention is called a “step”. Before and after each step, the dependent variable of interest is measured in all clusters. The analysis of data from such a design involves the comparison of the intervention “wedge” (i.e., data ...
A stepped wedge cluster randomised controlled trial of a healthy lifestyle intervention for people attending residential substance abuse treatment,University of Wollongong,Interventional,Not Applicable
The fixed effects model is a useful alternative to the mixed effects model for analyzing stepped-wedge cluster randomized trials (SW-CRTs). It controls for all time-invariant cluster-level confounders and has proper control of type I error when the number of clusters is small. While all cluster...
Systematic review of stepped wedge cluster randomized trials shows that design is particularly used to evaluate interventions during routine implementation To describe the application of the stepped wedge cluster randomized controlled trial (CRCT) design. Systematic review. We searched Medline, Embase, Psyc...
This study is a five-year stepped-wedge cluster-randomised trial conducted in a rural Cambodian province with an estimated annual delivery rate of 6615. The study is designed to implement and evaluate the Saving Babies’ Lives programme, which is the intervention. The Saving Babies’ Lives program...