The stepped-wedge (SW) cluster randomized controlled trial, in which clusters cross over in a randomized sequence from control to intervention, is ideal for the implementation and testing of complex health service interventions. In certain cases however, implementation of the intervention may pose ...
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In contrast, there is little research available pertaining to the design and analysis of multi-arm stepped-wedge cluster randomized trials, utilized to evaluate the effectiveness of multiple experimental interventions. In this paper, we address this by explaining how the required sample size in these...
Stepped Wedge Design A form of Cluster randomized controlled trial in which the intervention is administered in a random sequence to all clusters over time, so that all clusters will have received the intervention at the end of the trial. Each time point at which a new cluster receives the ...
The use of Stepped Wedge cluster randomized trials: Systematic Review Dr Celia Taylor The University of Birmingham On behalf of my co-authors: Noreen Mdege, Mei-See Man and David Torgerson (University of York) Today’s presentation What is a stepped wedge design? What are the advantages and...
Using theoretical calculations and simulation we have investigated statistical characteristics of the stepped wedge design for cluster randomized trials. In particular, we have outlined a procedure for computing power in such trials and investigated the effect of varying intercluster correlation, number of...
Conclusion: These stepped wedge design variations offer alternative methods for studying two interventions using a cluster-randomized trial. The selection of the appropriate variants should be driven by the research question with consideration given to the trade-off in number of steps, number of ...
The stepped-wedge cluster randomized design has been increasingly employed by pragmatic trials in health services research. In this study, based on the GEE approach, we present closed-form sample size calculation that is applicable to both closed-cohort and cross-sectional stepped wedge trials. Impor...
Improving efficiency in the stepped-wedge trial design via Bayesian modeling with an informative prior for the time effects: In a cross-sectional stepped-wedge cluster randomized trial comparing usual care to a new intervention, treatment allocation and time are correlated by des... D Zhan,Y Ouyan...
Background: Stepped wedge cluster randomized trials are a class of unidirectional crossover studies that have historically been limited to evaluating a single intervention. This design is especially suitable for pragmatic trials where th... VH Lyons,L Li,J Hughes,... 被引量: 2发表: 2017年 The...