The stepped-wedge (SW) cluster randomized controlled trial, in which clusters cross over in a randomized sequence from control to intervention, is ideal for the implementation and testing of complex health serv
In stepped wedge (SW) designs, differing cluster-level characteristics or individual-level covariate distributions that differ by cluster can lead to imbalance by treatment arm and potential confounding of the treatment effect. Adapting a method used in cluster-randomized trials, we propose a covariate...
[1] 杨祖耀,詹思延. 阶梯设计在随机对照试验中的应用. 中华流行病学杂志, 2010. 31(1): 第92-95页. [2] Li, S., et al., Rational and design of astepped-wedgeclusterrandomized trial evaluating quality improvement initiativefor reducing cardiovascular ...
stepped wedgeStandard sample size calculation formulas for stepped wedge cluster randomized trials (SW〤RTs) assume that cluster sizes are equal. When cluster sizes vary substantially, ignoring this variation may lead to an under﹑owered study. We investigate the relative efficiency of a SW〤RT ...
The Devon Active Villages Evaluation (DAVE) trial: study protocol of a stepped wedge cluster randomised trial of a community-level physical activity intervention in rural southwest England. BMC Public Health. 2012;12(1):581. CentralSolomon E, Rees T, Ukoumunne OC, Hillsdon M: The Devon ...
The use of Stepped Wedge cluster randomized trials: Systematic Review Dr Celia Taylor The University of Birmingham On behalf of my co-authors: Noreen Mdege, Mei-See Man and David Torgerson (University of York) Today’s presentation What is a stepped wedge design? What are the advantages and...
The ability to accurately estimate the sample size required by a stepped-wedge (SW) cluster randomized trial (CRT) routinely depends upon the specification of several nuisance parameters. If these parameters are mis-specified, the trial could be over-powered, leading to increased cost, or under-...
Tele-Kasper is a stepped-wedge cluster-randomized trial that will be conducted across non-university children’s hospitals in Germany. The intervention consists of a telemedical consultation service in the form of a network in different German areas, using an app as a communication tool. The ...
Design and analysis of stepped wedge cluster randomized trials. Contemp Clin Trials. 2007;28(2):182–91. 10.1016/j.cct.2006.05.007. Article PubMed Google Scholar Kekwaletswe CT, Morojele NK. Alcohol use, antiretroviral therapy adherence, and preferences regarding an alcohol-focused adherence ...
Methods Trial design This hybrid design trial will include a cluster randomized stepped-wedge design to assess effectiveness and a realist process evaluation to assess implementation outcomes, conducted over 45 months from 2022 to 2024 (Fig. 1). The stepped wedge trial will include three ...