答案是:阶梯设计(the stepped-wedge design) 阶梯设计多用于整群随机试验,评价“利大于弊”的干预措施,尤其在健康教育、免疫接种、筛检、医护人员培训等领域使用较多。这种设计通常不设置专门的对照组,随着试验的进行,各个组都会按照随机结果先后接受这种干预措施。这样就...
Stepped-wedge cluster randomised controlled trials: a generic framework including parallel and multiple-level designs. Statist Med. 2015;34:181-96.K. Hemming, R. Lilford, A.J. Girling, Stepped-wedge cluster randomised controlled trials: a generic framework including parallel and multiple-level ...
In Section 2 we describe a trial being conducted in Washington state that uses a stepped wedge design. This motivating example provides a context for the theoretical and simulation results shown in Section 3 where we describe statistical aspects of the design and analysis of stepped wedge CRTs. ...
STEPPED WEDGE,A 222 781 01 11Part Info Location Of Picture: 460 Main Group: Sliding Roof Diagram: PANORAMIC ROOF Remark: TOLERANCE COMPENSATION 1,5MM-3,0MM ModelModelYearEngineKWCCTransmissionFuelBody StyleFront BrakeRear BrakeParking BrakeDrive 奔驰[ 北京奔驰 ] C级 C级 (W205/V205) 2014...
The analysis of data from such a design involves the comparison of the intervention “wedge” (i.e., data from the clusters that have received the intervention during a step) with the control wedge... ... Access to the complete content on Oxford Reference requires a subscription or purchas...
Stepped wedge trials are randomized trials in which each randomization unit first receives the control condition and then crosses over to receive the intervention. However, the time at which the intervention is provided to each unit is randomized. Stepped wedge trials may be either individually or ...
In contrast, there is little research available pertaining to the design and analysis of multi-arm stepped-wedge cluster randomized trials, utilized to evaluate the effectiveness of multiple experimental interventions. In this paper, we address this by explaining how the required sample size in these...
In a stepped wedge design, schools are randomised to a sequence of measurements, with each sequence transitioning to intervention status at a different time. There are several advantages to such designs, including increased statistical power, logistical benefits and the ability to explore change over ...
O2 Stepped wedge trials with non-uniform correlation structure Andrew Forbes, Karla Hemming O3 Challenges and solutions for the operationalisation of the ENHANCE study: a pilot stepped wedge trial within a general practice setting Sarah A Lawton, Emma Healey, Martyn Lewis, Elaine Nicholls, Clare Jink...
In a stepped wedge, cluster randomised trial, clusters receive the intervention at different time points, and the order in which they received it is randomised. Previous systematic reviews of stepped wedge trials have documented a steady rise in their use between 1987 and 2010, which was attribute...