CD8+ T cellsstemnesstumor immunotherapyin vivo to achieve enhanced antitumor effects.Stem-like memory T cells for better proliferation & survivalAccording to the current models [1,2], naive T cells, after antigen stimulation, will undergo activation, proliferation and stepwise differentiation into ...
The common γ-chain cytokines IL-7 and IL-15 have been demonstrated to preferentially generate and expand TSCM-like cells from ex vivo-stimulated, naive human CD8+ T cells22. We therefore sought to determine whether culturing our TCR-engineered CD4+ T cells in IL-7/IL-15, rather than IL...
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses. Nat. Immunol. 23, 836–847 (2022). Article CAS PubMed Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. ...
cell RNA-sequencing data to map the organizational structure of the human CD8+memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally distinct stem-like CD8+memory T cells. Progenitors...
Stem Cell 14155 StemSep Human Naive CD4+ T Cells, 2 mL ￥11,422.00 Stem Cell 14156 StemSep Human Eosinophil Cells, 2 mL ￥9,301.00 Stem Cell 14161 Special StemSep Human Granulocyte Kit ￥57,568.00 Stem Cell 14162 Special StemSep Hu Epithelial Tumo,10 mL ￥65,350.00 ...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most efficient therapeutic options available to cure many hematological malignancies. However, severe complications derived from this procedure, including graft-versus-host dise
Stem Cell Research & Therapy volume 16, Article number: 33 (2025) Cite this article Metrics details Abstract A large body of evidence suggests that mesenchymal stromal cells (MSCs) are able to respond rapidly to the cytokine milieu following systemic infusion. This encounter has the potential to...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most efficient therapeutic options available to cure many hematological malignancies. However, severe complications derived from this procedure, including graft-versus-host dise
A recent study, using a highly sensitive, enrichment-based technique, identified the naïve CD8+ T cell precursor frequency for the SL9 epitope in uninfected HLA-A*0201 individuals as approximately one in 3.3 × 106 cells in the peripheral blood (Alanio et al., 2010). This precursor ...
Stemberger C, Neuenhahn M, Gebhardt FE et al (2009) Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets. Semin Immunol 21:62... C Stemberger,M Neuenhahn,FE Gebhardt,... - 《Seminars in Immunology》 被引量: 88发表: 2009年 Long-lasting stem cell-like memory CD8...