同时,STAT5诱导的NAMPT将黑色素瘤细胞转向与靶向治疗耐药相关的侵袭表型。 除了促进NAD+生物发生外,癌细胞中NAMPT的表达增加了α-酮戊二酸(α-KG)水平,导致程序性细胞死亡配体1(PD-L1)通过STAT1依赖性IFN-γ途径上调。因此,癌细胞中NAMPT表达的升高和NAD+代谢的上调抑制了CD8+T细胞依...
为了确定Setd2对免疫治疗反应的影响,同等数量的KC-sgSetd2和对照细胞皮下移植到C57BL/6免疫活性小鼠中,然后腹腔注射PD-L1抗体。与载体对照相比,PD-L1治疗显著减少了KC-sgSetd2肿瘤的生长,但对对照组肿瘤大小没有影响(图1B-E)。这些结果表明,Setd2基因敲除可使胰腺癌对PD-L1免疫治疗敏感。为了验证该结论,作...
PD-L1 expression status is a key determinant of whether a patient will respond to immunotherapy [16]. Therefore, there is an urgent need to investigate the molecular regulatory mechanisms of PD-L1 expression in malignant cells, especially in pancreatic cancer. In this research, we examined the ...
Neutrophil infiltration into the lung and liver was also reduced in PD-L1/mice 16h after sepsis induction. PKM2 was upregulated in septic neutrophils and promoted neutrophil PD-L1 expression both in vitro and in vivo. In addition, PKM2 nuclear translocation was increased after LPS stimulation, ...
Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1...
PD-L1-mediated EMT. Luciferase reporter assays were performed to examine the IFIT2 promoter activities upon knockdown expression of PD-L1 to identify the putative targeted region of IFIT2 promoter.Results The STAT1/IFIT2 signal pathway was activated when PD-L1 was knockdown in human esophageal ...
其表达缺失与肿瘤细胞PD-L1高表达有关。 PIAS 是细胞因子激活的STAT蛋白抑制物,能够物理阻断核内激活的STAT与DNA结合,从而阻止信号诱导。 PIAS1能够抑制Ⅰ/Ⅱ型IFN→STAT1信号传递,在多种恶心肿瘤中表达升高。 PIAS3被沉默时,会导致STAT3过度激活。 PTP
(STAT1) activation, which promotes transcription of the STAT1 target gene, PD-L1. The findings highlight the regulatory mechanism of PD-L1 expression on neutrophils during sepsis. This involves the non-metabolic role of the glycolytic enzyme, PKM2, which provides potential targets to modulate ...
表明HKDC1以一种依赖于其与肌动蛋白丝结合的方式增强STAT1的磷酸化。 HKDC1向IFNGR1呈递细胞质STAT1,通过ACTA2促进其磷酸化(Ref. Fig4) 全文分享可查阅:【《Nat Commun》文献解读:己糖激酶有新功能!HKDC1通过结合细胞骨架与STAT1活化和PD-L1表达参与肝癌免疫逃避】。
Programmed death-ligand 1 (PD-L1) acts as an immune checkpoint inhibitor in various cancers. PD-L1 is known to be more frequently expressed in EBV (+) gastric cancer (GC). However, the mechanisms underlying the regulation of PD-L1 expression in EBV (+) G