结果:PD-L1和pSTAT3蛋白表达阳性率分别为37.8%(28/74)和54.1%(40/74),PD-L1蛋白表达与组织学分化程度(P=0.002)和淋巴结转移(P=0.03)相关.p-STAT3蛋白表达与淋巴结转移相关(P=0.015).Spearman相关性分析发现PD-L1与p-STAT3蛋白表达呈正相关,但无统计学差异.Kaplan-Meier生存分析显示PDL1和p-STAT3表达阳性...
pSTAT3 overexpression in RA is associated with PDL1 expression and may negatively impact the i-PFS in BM from NSCLC. These data support the investigation of STAT3 inhibitor silibinin in preventing intracranial recurrence in a clinical trial (NCT05689619).Pellerino Alessia...
PDL1JAK/STAT3Non-small cell lung cancer (NSCLC) is a life-threatening disease that still lacks effective targeted treatment. Family with sequence similarity 64, member A (FAM64A) is dysregulated in different malignancies and participates in the cancer progression. To address the role of FAM64A ...