The aim of the present study was to assess the expression levels of STAT3, and the protein levels of IL-6 and sPD-L1 in EA. In the present retrospective study, data were retrieved from the medical records of 137 patients with EA who received surgical treatment at The First Affiliated ...
[1]. Tang J, Yu JX, Hubbard-Lucey VM, Neftelinov ST, Hodge JP, Lin Y. Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors. Nat Rev Drug Discov. 2018;17(12):854-855. doi:10....
Firstly, when the CRPC cell lines C4-2 and CWR22Rv1 were induced by hypoxia, the expression of the UL16 binding protein (ULBP) ligand family of natural killer (NK) group 2D (NKG2D; ULBP-1, ULBP-2 and ULBP-3) and MHC class I chain-related proteins A and B (MICA/MICB) ...
The STAT signal is a transcription factor found in the cytoplasm and is a well-known oncogenic signaling pathway. It mediates signaling pathways through cellular receptors and is involved in various cellular activities, including immune response, cellular respiration, differentiation, renewal, and prolifer...
HCC-CAF-primed neutrophils impaired T-cell function through the PD1/PDL1 signaling pathway. We revealed that HCC-CAFs induced the activation of STAT3 pathways in neutrophils, which are essential for the survival and function of activated neutrophils. In addition, we demonstrated that HCC-CAF-...
4F-G). There were significantly increased cells expressing checkpoint protein PDL1 (p = 0.0087) but not PD1 (p = 0.1744) (Fig. 4H-I). The % of Ki67 + tumor cells was significantly lower in tumors with high pSTAT3 (p = 0.0002) (Fig. 4J). Fig. 4 Immune and ...
STAT3ε and STAT3ζ (shown in Table1). These isoforms determine the distinct functions of STAT3. STAT3α is the longest isoform, commonly designated as STAT3, and contributes most to the canonical functions of STAT3. STAT3 consists of 24 exons. STAT3β is generated by alternative splicing at ...
Our previous study showed that metformin inhibits the proliferation of lung cancer cells and exerts anti-tumor effects in an AMPK-C/EBPβ-PDL1 signaling-dependent manner [45]. In our study, both single-cell data and in vitro experiments revealed that C/EBPβ can regulate IL-6 expression, ...
Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. Cell Death Dis. 2018;9:422. 126. Li S, Cong X, Gao H, Lan X, Li Z, Wang W, et al. Tumor-associated neutrophils induce EMT by IL-17a to ...
[1]. Tang J, Yu JX, Hubbard-Lucey VM, Neftelinov ST, Hodge JP, Lin Y. Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors. Nat Rev Drug Discov. 2018;17(12):854-855. doi:10.1038/nrd.2018.210