SREBP-1是增加肝脏脂肪酸和甘油三酯合成的主要转录因子，本文回顾了近年来以SREBP-1相关通路为靶点NAFLD 的研究进展。 关键词 甾醇调节元件结合蛋白-1，非酒精性脂肪性肝病，信号通路，脂质生成 The Pathogenesis and Treatment Progress of NAFLD Targeted by SREBP-1 Related Pathway Ruolan Zhu, Bo Ning Chongqing ...
Salicylic acid treats acne vulgaris by suppressing AMPK AMPK / SREBP SREBP 1 pathway in sebocytesacne vulgarisinflammationNF ‐κBsalicylic acidsebocyteSREBP ‐1Acne vulgaris is a prevalent cutaneous disease characterized by a multifactorial pathogenic process including hyperseborrhea, inflammation, over‐...
[5] Tse AP, Sze KM, Shea QT, et al. Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer[J]. Oncogenesis, 2018, 7(5): 44. DOI: 10.1038/s41389- ...
[9]Brown MS, Goldstein JL: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997;89:331-340. [10]Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osug...
SREBP-1 regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. It binds to the sterol regulatory element 1 (SRE-1) (5′-ATCACCCCAC-3′) and has dual sequence specificity binding to both an E-box motif (5′-...
ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway 来自 Elsevier 喜欢 0 阅读量: 249 作者:JCABC D,CDA B,YCABC D,WH A,CY A,CP A,XF A,QC A,WW A,YL A 摘要: Lipid metabolic reprogramming plays a pivotal role in hepatocellular carcinoma (HCC) ...
Through Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, we found that several Discussion Increasing evidence indicates that lipid reprogramming is involved in tumor growth, metastasis and resistance to therapies. Deregulation of lipogenesis has been regarded as a carcinogenic ...
pathway are potential drug targets for cancer therapy. SREBP-1 is a key transcription factor which regulates the expression of key enzymes in cholesterol or fatty acids synthesis and controls lipogenesis. The expression and activity of SREBP-1 and its regulated fatty acid synthesis pathway are low ...
The thyroid hormone 3,5,3′-triiodo-L-thyronine (T3) increases the expression of SREBP-1, apparently by binding to the integrin receptor αvβ3 and activating the PI3K-Akt-mTORC1 pathway in HepG2 cells, as suggested by inhibitor studies [86]. Protein kinase C-alpha (PKC-α) seems to...
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell, 1997, 89(3): 331-340. [23] 付常振,昝林森,王虹,成功,王洪宝,李耀坤,姜碧杰,高建 斌,杨宁. 牛 SREBP1 基因 shRNA 序列的筛选及其腺病毒载体的 构建与鉴定. 中国农业科学, 2013, ...