SREBP-1是增加肝脏脂肪酸和甘油三酯合成的主要转录因子，本文回顾了近年来以SREBP-1相关通路为靶点NAFLD 的研究进展。 关键词 甾醇调节元件结合蛋白-1，非酒精性脂肪性肝病，信号通路，脂质生成 The Pathogenesis and Treatment Progress of NAFLD Targeted by SREBP-1 Related Pathway Ruolan Zhu, Bo Ning Chongqing ...
But there are impressive contradictions regarding the highly questionable physiological (nutritional regulation) and pathophysiological (e.g., NAFLD/NASH, diabetes mellitus type 2, viral hepatitis and hepatocarcinoma) role of SREBP1c in hepatic lipid metabolism. ...
and is often accompanied by hepatitis B virus (HBV) infection or non-alcoholic steatohepatitis (NASH) as leading risk factors [1,2]. Malignant transformation to HCC is associated with intense metabolic reprogramming, particularly related to lipid uptake, biosynthesis, (subcellular...
Yet, our understanding of how a major fibrosis pathway, transforming growth factor β (TGF-β), and how members, SMAD3 with its adaptor SPTBN 1 -contribute to the progression of NASH-driven HCC remains unclear. Here, we sought to better understand the role of TGF-β1/SMAD3/SPTBN1 in ...
结论 替米沙坦干预NASH大鼠可显著减改善肝功能和IR,其机制并非抑制炎症因子IL-6,而是下调肝脏SOCS-3、SREBP-1c的表达,从而改善糖脂代谢和NASH。 关键词:非酒精性脂肪性肝炎;胰岛素抵抗;SOCS-3;SREBP-1c;替米沙坦 Abstract: Objective To evaluate the effects of telmisartan by SOCS-3/SREBP-1c pathway and its...
hepatitis,NASH)作为其疾病发展的重要 中间阶段也 越来越引起人们的兴趣 ,但其分子机制至今尚不完 全清楚I11。已有研究表 明炎症因子在促进肝细胞脂 肪变性及加重肝细胞脂质代谢紊乱 中起 了重要作 用[2],但其具体分子机制仍不清楚。固醇调节元件结 合蛋白 1( sterol regulatory element binding proteins...
MVP Mevalonate pathway NAD+ Nicotinamide adenine dinucleotide NAFLD Non-alcoholic fatty liver disease NASH Nonalcoholic steatohepatitis NRCMs Neonatal rat cardiomyocytes OA Oleic acid OHA Oral hypoglycemic agents ox-LDL Oxidized low-density lipoprotein PA Palmitic acid PGC-1α Proliferator-activated receptor...
The change in fatty acid composition of PIs in these mice was associated with a marked increase in de novo lipogenesis because of activation of SREBP-1c, a transcription factor that coordinates the activation of genes encoding enzymes in the fatty acid biosynthesis pathway. Hepatic removal of ...
非酒精性脂肪性肝病(NAFLD)是指除外酒精和其他明确的损肝因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征,包括单纯性脂肪肝以及由其演变的脂肪性肝炎(NASH)和肝硬化[ 1 ] 。NAFLD的患病率逐年上升, 已成为全球普遍关注的医学问题和社会问题。
Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/ SCD1 signaling pathway and modulating gut microbiota. Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/ SCD1 signaling pathway and modulating gut microbiota.NASH...