Moreover, a functional role for SREBP‐1a in macrophages has not been addressed. We established a line of mice that resulted in a greater than 95% knockdown in SREBP‐1a mRNA in every tissue examined using a β‐geo "gene trap"system. In this study, we show that macrophages from these ...
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However, SREBP functions beyond lipid metabolism are less understood. Here, we show that hepcidin antimicrobial peptide ( Together, these results indicate that the SREBP-1a/c transcription regulators activate hepcidin expression and thereby contribute to the control of mammalian iron metabolism. Published...
Third, promoters of lipogenic enzymes containing variations of SRE (SRE-like sequences) are strongly activated by SREBP-1a, and only modestly and equally by both SREBP-1c and -2. Finally, substitution of the unique tyrosine residue within the basic helix-loop-helix (bHLH) portion of nuclear ...
p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A. Oncogene. 2016; 35:1399-1410.p54nrb/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A. Zhu Z,Zhao X,Zhao L,et al. Oncegene . 2015...
International Journal of Molecular Sciences Article Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes Birgit Knebel 1,2 ID , Sonja Hartwig 1,2, Sylvia Jacob 1,2...
Cytokine secretion into plasma or cell culture supernatants after 24 h incubation with the test mAbs (anti-CD28 superagonist TGN1412-like material (TGN1412L), another anti-CD28 superagonistic mAb (ANC28.1), a T-cell depleting mAb (Orthoclone (TM)), and a TGN1412 isotype-matched control (...
Anti SREBP-1a, clone 2121|Anti SREBP-1a, clone 2121| 基本信息 更多信息 中文名称: 中文同义词: 英文名称: Anti SREBP-1a, clone 2121 英文同义词: Anti SREBP-1a, clone 2121 CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览Anti SREBP-1a, clone 2121国外供应商...
2022年2月9日,来自加拿大麦克马斯特大学的研究团队在Nature communication杂志上发表的一项题为Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance的研究发现,咖啡因能够降低PCSK9,增加肝...