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Recently, a polymorphism in the 5′-region of the SREBP-1a gene has been described to be correlated with alterations in the plasma levels of cholesterol. Consequently the relationship between this SREBP-1a gene polymorphism and Alzheimer’s disease (AD) alone and in combination with the ...
获得的主要研究结果如下:(1)通过对山羊基因组序列及SREBP-1基因cDNA序列的比对,利用启动子克隆技术,扩增得到山羊SREBP-1a及SREBP-1c基因的启动子序列,分别包括转录起始位点上游1 947 bp及2 012 bp.将克隆得到的启动子序列分别构建启动子荧光素酶报告基因载体(pGL3-basic),转染山羊原代乳腺上皮细胞,48 h后检测...
the physiological relevance of this potent activity of SREBP-1a has been thought to regulate the supply of membrane lipids in response to cell growth. Here we show that nuclear SREBP-1a and SREBP-2 bind directly to a novel SREBP binding site in the promoter of the p21(WAF1/CIP1) gene, ...
第一部分p54~(nrb)/NONO通过SREBP-1a调节脂质代谢促进乳腺癌增殖机制的研究目的:研究p54~(nrb)/不含POU结构域的八聚核苷酸结合蛋白(non-POU-dormain-containing octamer-bindingprotein,NONO)通过胆固醇调节元件蛋白(Sterol regμlatory element-binding proteins-1a,SREBP-1a)调节脂质代谢,促进乳腺癌增殖的分子机制。...
Third, promoters of lipogenic enzymes containing variations of SRE (SRE-like sequences) are strongly activated by SREBP-1a, and only modestly and equally by both SREBP-1c and -2. Finally, substitution of the unique tyrosine residue within the basic helix-loop-helix (bHLH) portion of nuclear ...
p54nrb/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A. Oncogene, 2015, 35: 1399-410Zhu Z, Zhao X, Zhao L, Yang H, Liu L, Li J, Wu J, Yang F, Huang G, Liu J. p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A. Oncogene....
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